Bioactive sphingolipids—ceramide, sphingosine, and their respective 1-phosphates (C1P
and S1P)—are signaling molecules serving as intracellular second messengers. Moreover …

Sphingolipids are a class of lipids highly enriched in the central nervous system (CNS),
which shows great diversity and complexity, and has been implicated in CNS development …

The heterogeneity of biological processes driving the severity of nonalcoholic fatty liver
disease (NAFLD) as reflected in the transcriptome and the relationship between the …

The central nervous system is characterized by a high content of sphingolipids and by a high
diversity in terms of different structures. Stage-and cell-specific sphingolipid metabolism and …

The cholinergic system plays an essential role in brain development, physiology, and
pathophysiology. Herein, we review how specific alterations in this system, through genetic …

Huntington disease (HD) is a debilitating, currently incurable disease. Protein aggregation
and metabolic deficits are pathological hallmarks but their link to neurodegeneration and …

Neurodegenerative diseases represent a class of fatal brain disorders for which the number
of effective therapeutic options remains limited with only symptomatic treatment accessible …

Sphingosine 1-phosphate (S1P), derived from membrane sphingolipids, is a pleiotropic
bioactive lipid mediator capable of evoking complex immune phenomena. Studies have …

Huntington's disease (HD) is increasingly recognized for diverse pathology outside of the
nervous system. To describe the biology of HD in relation to functional progression, we …

Altered cellular metabolism is believed to be an important contributor to pathogenesis of the
neurodegenerative disorder Huntington's disease (HD). Research has primarily focused on …