Advances in non-hormonal male contraception targeting sperm motility

NAP Mariani, JV Silva, M Fardilha… - Human Reproduction …, 2023 - academic.oup.com
BACKGROUND The high rates of unintended pregnancy and the ever-growing world
population impose health, economic, social, and environmental threats to countries …

Signaling enzymes required for sperm maturation and fertilization in mammals

S Dey, C Brothag, S Vijayaraghavan - Frontiers in Cell and …, 2019 - frontiersin.org
In mammals, motility and fertilizing ability of spermatozoa develop during their passage
through the epididymis. After ejaculation, sperm undergo capacitation and hyperactivation in …

[HTML][HTML] Sperm redox biology challenges the role of antioxidants as a treatment for male factor infertility

E Caroppo, M Dattilo - F&S Reviews, 2022 - Elsevier
In spite of inconclusive or negative outcomes from clinical studies, oral antioxidants are still
largely prescribed to infertile men to improve sperm motility and/or reduce sperm DNA …

Comparative whole-genome resequencing to uncover selection signatures linked to litter size in Hu Sheep and five other breeds

T Zhong, D Hou, Q Zhao, S Zhan, L Wang, L Li… - BMC genomics, 2024 - Springer
Hu sheep (HS), a breed of sheep carrying the FecB mutation gene, is known for its “year-
round estrus and multiple births” and is an ideal model for studying the high fecundity …

[HTML][HTML] Disruption of protein phosphatase 1 complexes with the use of bioportides as a novel approach to target sperm motility

JV Silva, MJ Freitas, J Santiago, S Jones… - Fertility and …, 2021 - Elsevier
Objective To design protein phosphatase 1 (PP1)–disrupting peptides covalently coupled to
inert cell-penetrating peptides (CPPs) as sychnologically organized bioportide constructs as …

Bifenthrin Diminishes Male Fertility Potential by Inducing Protein Defects in Mouse Sperm

JW Bae, JM Hwang, M Yoon, WS Kwon - Toxics, 2024 - mdpi.com
A synthetic pyrethroid pesticide, bifenthrin, has been commonly used as an effective
exterminator, although the rise in its usage has raised concerns regarding its effects on the …

Target silencing of porcine SPAG6 and PPP1CC by shRNA attenuated sperm motility

H Ren, Y Zhang, Y Bi, H Wang, G Fang, P Zhao - Theriogenology, 2024 - Elsevier
The quality of sperm significantly influences the reproductive efficiency of pig herds. High-
quality sperm is necessary for efficient fertilization and to maximize the litter numbers in …

[HTML][HTML] 犏牛PPP1R11基因的克隆及在睾丸中的表达规律研究

闵星宇, 杨丽雪, 于海玲, 胡宇磊, 杨满珍, 杨璐瑜… - 畜牧兽医学报, 2022 - xml-data.org
旨在克隆犏牛蛋白磷酸酶1 调节亚基11 (protein phosphatase 1 regulatory subunit 11,
PPP1R11) 基因, 分析其在不同发育阶段睾丸中的表达与定位, 为解析其在雄性生殖中的功能 …

Some Aspects of the Role of Phosphorylation in Regulation of Spermatozoa Motility in Microgravity

MA Golubkova, IV Ogneva - Human Physiology, 2022 - Springer
The review describes mechanisms of regulating the spermatozoa motor activity. The authors
present the enzymes involved in phosphorylation of axonemal proteins, action of various …

[图书][B] Basis for the Essential Role of the Mammal-Specific Protein Phosphatase Isoform PP1γ2 in Sperm

WO Nofal - 2023 - search.proquest.com
In mammals, testicular sperm exiting the seminiferous tubules are immotile. Mammalian
sperm gain motility and the ability to fertilize eggs during their passage through the …