Nucleosomes are efficient DNA-packaging units. The fundamental protein unit of the
nucleosome is the histone dimer, a simple α-helical domain possessing a highly basic …

Nucleosome positioning is critical for gene expression and most DNA-related processes.
Here we review the dominant patterns of nucleosome positioning that have been observed …

The packaging of chromosomal DNA by nucleosomes condenses and organizes the
genome, but occludes many regulatory DNA elements. However, this constraint also allows …

Histones are characterized by numerous posttranslational modifications that influence gene
transcription,. However, because of the lack of global distribution data in higher eukaryotic …

Histone modifications not only play important roles in regulating chromatin structure and
nuclear processes but also can be passed to daughter cells as epigenetic marks …

Chromatin structure imposes significant obstacles on all aspects of transcription that are
mediated by RNA polymerase II. The dynamics of chromatin structure are tightly regulated …

Elongation is becoming increasingly recognized as a critical step in eukaryotic
transcriptional regulation. Although traditional genetic and biochemical studies have …

Chromatin is a highly regulated nucleoprotein complex through which genetic material is
structured and maneuvered to elicit cellular processes, including transcription, cell division …

Comparative genomics of nucleosome positions provides a powerful means for
understanding how the organization of chromatin and the transcription machinery co-evolve …

Understanding the mechanisms by which chromatin structure controls eukaryotic
transcription has been an intense area of investigation for the past 25 years. Many of the key …