Summary Introduction Matrix metalloproteinases (MMPs) and 'aggrecanase'a disintegrin
and metalloproteinase with thrombospondin motifs (ADAMTSs) are well established to play …

The ADAMs family of transmembrane proteins belongs to the zinc protease superfamily.
Members of the family have a modular design, characterized by the presence of …

Mammalian cells proteolytically release (shed) the extracellular domains of many cell-
surface proteins1. Modification of the cell surface in this way can alter the cell's …

Tumour-necrosis factor-α (TNF-α) is a cytokine that contributes to a variety of inflammatory
disease states1. The protein exists as a membrane-bound precursor2, 3 of relative …

ADAM (a disintegrin and metalloprotease) proteins are membrane-anchored
metalloproteases that process and shed the ectodomains of membrane-anchored growth …

Human telomeres are composed of long arrays of TTAGGG repeats that form a
nucleoprotein complex required for the protection and replication of chromosome ends. One …

It has been puzzling that mammalian telomeric proteins, including TRF1, TRF2, tankyrase,
and TIN2 have no recognized orthologs in budding yeast. Here, we describe a human …

A cellular disintegrin and metalloproteinase (ADAM) is a new family of genes with structural
homology to the snake venom metalloproteinases and disintegrins. We screened genes …

Tumor necrosis factor (TNF)-related activation-induced cytokine (TRANCE), a member of the
TNF family, is a dendritic cell survival factor and is essential for osteoclastogenesis and …

Tumour necrosis factor α convertase (TACE) is a metalloprotease/disintegrin involved in the
ectodomain shedding of several proteins, a process thought to be important in inflammation …