Antibodies against angiotensin II type 1 and endothelin 1 type A receptors in cardiovascular pathologies

G Civieri, L Iop, F Tona - International Journal of Molecular Sciences, 2022 - mdpi.com
Angiotensin II receptor type 1 (AT1R) and endothelin-1 receptor type A (ETAR) are G-protein-
coupled receptors (GPCRs) expressed on the surface of a great variety of cells: immune …

The emerging field of non–human leukocyte antigen antibodies in transplant medicine and beyond

C Lefaucheur, K Louis, A Philippe, A Loupy… - Kidney International, 2021 - Elsevier
The major medical advances in our knowledge of the human leukocyte antigen (HLA)
system have allowed us to uncover several gaps in our understanding of alloimmunity …

[HTML][HTML] Sensitization in transplantation: assessment of risk 2022 working group meeting report

AR Tambur, O Bestard, P Campbell, AS Chong… - American Journal of …, 2023 - Elsevier
Abstract The Sensitization in Transplantation: Assessment of Risk workgroup is a
collaborative effort of the American Society of Transplantation and the American Society of …

Autoantibodies from patients with kidney allograft vasculopathy stimulate a proinflammatory switch in endothelial cells and monocytes mediated via GPCR-directed …

G Moll, C Luecht, MA Gyamfi, DLM da Fonseca… - Frontiers in …, 2023 - frontiersin.org
Non-HLA-directed regulatory autoantibodies (RABs) are known to target G-protein coupled
receptors (GPCRs) and thereby contribute to kidney transplant vasculopathy and failure …

Non-HLA antibodies targeting angiotensin II Type 1 receptor and endothelin-1 Type A receptors induce endothelial injury via β2-arrestin link to mTOR pathway

RA Catar, O Wischnewski, L Chen, H Heidecke… - Kidney International, 2022 - Elsevier
Functional non-HLA antibodies (antibodies to non-human leukocyte antigens) targeting the
G protein-coupled receptors angiotensin II type 1 receptor (AT1R) and endothelin-1 type A …

The role of endothelin II type A receptor (ETAR) in transplant injury

K Nowańska, K Wiśnicki, M Kuriata-Kordek… - Transplant …, 2022 - Elsevier
Purpose of review Antibody-mediated rejection is the leading cause of deterioration of graft
function and graft loss after kidney transplantation. Recent studies have reported an …

[HTML][HTML] Evaluation of non-invasive biomarkers of kidney allograft rejection in a prospective multicenter unselected cohort study (EU-TRAIN)

V Goutaudier, R Danger, RA Catar, M Racapé… - Kidney International, 2024 - Elsevier
Non-invasive biomarkers are promising tools for improving kidney allograft rejection
monitoring, but their clinical adoption requires more evidence in specifically designed …

Vascular and Non-HLA autoantibody profiles in hospitalized patients with COVID-19

B Lichtenstein, Y Zheng, D Gjertson… - Frontiers in …, 2023 - frontiersin.org
Introduction Severe COVID-19 illness is characterized by an overwhelming immune
hyperactivation. Autoantibodies against vascular, tissue, and cytokine antigens have been …

Non-HLA antibodies in kidney transplantation: immunity and genetic insights

BM Sorohan, C Baston, D Tacu, C Bucșa, C Țincu… - Biomedicines, 2022 - mdpi.com
The polymorphic human leukocyte antigen (HLA) system has been considered the main
target for alloimmunity, but the non-HLA antibodies and autoimmunity have gained …

Effect of anti-angiotensin II type 1 receptor antibodies on the outcomes of kidney transplantation: a systematic review and meta-analysis

ZY Kang, C Liu, W Liu, DH Li - Nephrology Dialysis …, 2022 - academic.oup.com
Background Anti-angiotensin II type 1 receptor antibodies (AT1R-Abs) have been
recognized as non-human leukocyte antigen antibodies associated with allograft rejection …