Understanding the genetic regulatory code governing gene expression is an important
challenge in molecular biology. However, how individual coding and non-coding regions of …

Data-driven machine learning is the method of choice for predicting molecular phenotypes
from nucleotide sequence, modeling gene expression events including protein-DNA …

Conjugative relaxases are well-characterized proteins responsible for the site-and strand-
specific endonucleolytic cleavage and strand transfer reactions taking place at the start and …

Even though the use of antibiotics for food-producing animals may contribute to the
emergence of antimicrobial resistance, antibiotics are still used as growth promoters. Due to …

Conjugative plasmids are important drivers of bacterial evolution. Most plasmids lack genes
for conjugation and characterized origins of transfer (oriT), which has hampered our …

Abstract Background Horizontal Gene Transfer (HGT) is the process of transferring genetic
materials between species. Through sharing genetic materials, microorganisms in the …

Conjugation and mobilization are two important pathways of horizontal transfer of bacterial
mobile genetic elements (MGEs). The origin-of-transfer (oriT) region is crucial for this …

Background: A challenge in developing machine learning regression models is that it is
difficult to know whether maximal performance has been reached on the test dataset, or …

Catalyst development for biochemical cascade reactions often follows a “whole‐cell‐
approach” in which a single microbial cell is made to express all required enzyme activities …

Current evolutionary scenarios posit the emergence of Mycobacterium tuberculosis from an
environmental saprophyte through a cumulative process of genome adaptation …