Role of animal models in biomedical research: a review

P Mukherjee, S Roy, D Ghosh, SK Nandi - Laboratory Animal Research, 2022 - Springer
The animal model deals with the species other than the human, as it can imitate the disease
progression, its' diagnosis as well as a treatment similar to human. Discovery of a drug …

A roadmap for multi-omics data integration using deep learning

M Kang, E Ko, TB Mersha - Briefings in Bioinformatics, 2022 - academic.oup.com
High-throughput next-generation sequencing now makes it possible to generate a vast
amount of multi-omics data for various applications. These data have revolutionized …

Large animal models in regenerative medicine and tissue engineering: to do or not to do

I Ribitsch, PM Baptista, A Lange-Consiglio… - … in Bioengineering and …, 2020 - frontiersin.org
Rapid developments in Regenerative Medicine and Tissue Engineering has witnessed an
increasing drive toward clinical translation of breakthrough technologies. However, the …

The role of macrophages in the development of acute and chronic inflammatory lung diseases

JW Lee, W Chun, HJ Lee, JH Min, SM Kim, JY Seo… - Cells, 2021 - mdpi.com
Macrophages play an important role in the innate and adaptive immune responses of organ
systems, including the lungs, to particles and pathogens. Cumulative results show that …

Thymic stromal lymphopoietin: its role and potential as a therapeutic target in asthma

GM Gauvreau, R Sehmi, CS Ambrose… - Expert opinion on …, 2020 - Taylor & Francis
Introduction Thymic stromal lymphopoietin (TSLP), an epithelial cytokine (alarmin), is a
central regulator of the immune response to inhaled environmental insults such as …

Poor translatability of biomedical research using animals—A narrative review

LJ Marshall, J Bailey, M Cassotta… - Alternatives to …, 2023 - journals.sagepub.com
The failure rate for the translation of drugs from animal testing to human treatments remains
at over 92%, where it has been for the past few decades. The majority of these failures are …

Extracellular matrix component remodeling in respiratory diseases: what has been found in clinical and experimental studies?

JT Ito, JD Lourenço, RF Righetti, IFLC Tibério… - Cells, 2019 - mdpi.com
Changes in extracellular matrix (ECM) components in the lungs are associated with the
progression of respiratory diseases, such as asthma, chronic obstructive pulmonary disease …

Inhaled RNA therapy: from promise to reality

MYT Chow, Y Qiu, JKW Lam - Trends in pharmacological sciences, 2020 - cell.com
RNA-based medicine is receiving growing attention for its diverse roles and potential
therapeutic capacity. The largest obstacle in its clinical translation remains identifying a safe …

[HTML][HTML] Phthalate exposure and allergic diseases: Review of epidemiological and experimental evidence

AK Bølling, K Sripada, R Becher, G Bekö - Environment international, 2020 - Elsevier
Phthalates are among the most ubiquitous environmental contaminants and endocrine-
disrupting chemicals. Exposure to phthalates and related health effects have been …

[HTML][HTML] Cannabidiol reduces airway inflammation and fibrosis in experimental allergic asthma

F Vuolo, SC Abreu, M Michels, DG Xisto… - European journal of …, 2019 - Elsevier
Asthma is characterized by chronic lung inflammation and airway hyperresponsiveness.
Asthma remains a major public health problem and, at present, there are no effective …