Role of animal models in biomedical research: a review
The animal model deals with the species other than the human, as it can imitate the disease
progression, its' diagnosis as well as a treatment similar to human. Discovery of a drug …
progression, its' diagnosis as well as a treatment similar to human. Discovery of a drug …
A roadmap for multi-omics data integration using deep learning
High-throughput next-generation sequencing now makes it possible to generate a vast
amount of multi-omics data for various applications. These data have revolutionized …
amount of multi-omics data for various applications. These data have revolutionized …
Large animal models in regenerative medicine and tissue engineering: to do or not to do
I Ribitsch, PM Baptista, A Lange-Consiglio… - … in Bioengineering and …, 2020 - frontiersin.org
Rapid developments in Regenerative Medicine and Tissue Engineering has witnessed an
increasing drive toward clinical translation of breakthrough technologies. However, the …
increasing drive toward clinical translation of breakthrough technologies. However, the …
The role of macrophages in the development of acute and chronic inflammatory lung diseases
JW Lee, W Chun, HJ Lee, JH Min, SM Kim, JY Seo… - Cells, 2021 - mdpi.com
Macrophages play an important role in the innate and adaptive immune responses of organ
systems, including the lungs, to particles and pathogens. Cumulative results show that …
systems, including the lungs, to particles and pathogens. Cumulative results show that …
Thymic stromal lymphopoietin: its role and potential as a therapeutic target in asthma
Introduction Thymic stromal lymphopoietin (TSLP), an epithelial cytokine (alarmin), is a
central regulator of the immune response to inhaled environmental insults such as …
central regulator of the immune response to inhaled environmental insults such as …
Poor translatability of biomedical research using animals—A narrative review
LJ Marshall, J Bailey, M Cassotta… - Alternatives to …, 2023 - journals.sagepub.com
The failure rate for the translation of drugs from animal testing to human treatments remains
at over 92%, where it has been for the past few decades. The majority of these failures are …
at over 92%, where it has been for the past few decades. The majority of these failures are …
Extracellular matrix component remodeling in respiratory diseases: what has been found in clinical and experimental studies?
Changes in extracellular matrix (ECM) components in the lungs are associated with the
progression of respiratory diseases, such as asthma, chronic obstructive pulmonary disease …
progression of respiratory diseases, such as asthma, chronic obstructive pulmonary disease …
Inhaled RNA therapy: from promise to reality
RNA-based medicine is receiving growing attention for its diverse roles and potential
therapeutic capacity. The largest obstacle in its clinical translation remains identifying a safe …
therapeutic capacity. The largest obstacle in its clinical translation remains identifying a safe …
[HTML][HTML] Phthalate exposure and allergic diseases: Review of epidemiological and experimental evidence
Phthalates are among the most ubiquitous environmental contaminants and endocrine-
disrupting chemicals. Exposure to phthalates and related health effects have been …
disrupting chemicals. Exposure to phthalates and related health effects have been …
[HTML][HTML] Cannabidiol reduces airway inflammation and fibrosis in experimental allergic asthma
F Vuolo, SC Abreu, M Michels, DG Xisto… - European journal of …, 2019 - Elsevier
Asthma is characterized by chronic lung inflammation and airway hyperresponsiveness.
Asthma remains a major public health problem and, at present, there are no effective …
Asthma remains a major public health problem and, at present, there are no effective …