Diagnosis and management of multiple myeloma: a review

AJ Cowan, DJ Green, M Kwok, S Lee, DG Coffey… - Jama, 2022 - jamanetwork.com
Importance Multiple myeloma is a hematologic malignancy characterized by presence of
abnormal clonal plasma cells in the bone marrow, with potential for uncontrolled growth …

The multiple myelomas—current concepts in cytogenetic classification and therapy

SK Kumar, SV Rajkumar - Nature reviews Clinical oncology, 2018 - nature.com
Multiple myeloma (MM) is a plasma cell neoplasm that accounts for 2% of all haematological
malignancies and predominantly affects older individuals (with a median age at diagnosis of …

Multiple myeloma: 2022 update on diagnosis, risk stratification, and management

SV Rajkumar - American journal of hematology, 2022 - Wiley Online Library
Abstract Disease Overview Multiple myeloma accounts for approximately 10% of
hematologic malignancies. Diagnosis The diagnosis requires≥ 10% clonal bone marrow …

Second revision of the International Staging System (R2-ISS) for overall survival in multiple myeloma: a European Myeloma Network (EMN) report within the …

M D'agostino, DA Cairns, JJ Lahuerta… - Journal of clinical …, 2022 - ascopubs.org
PURPOSE Patients with newly diagnosed multiple myeloma (NDMM) show heterogeneous
outcomes, and approximately 60% of them are at intermediate-risk according to the Revised …

[HTML][HTML] Multiple myeloma: EHA-ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

MA Dimopoulos, P Moreau, E Terpos, MV Mateos… - …, 2021 - journals.lww.com
Since the publication of the article entitled “Multiple Myeloma: EHA-ESMO Clinical Practice
Guidelines for Diagnosis, Treatment and Follow-up”(HemaSphere. 2021; 5: e528) …

Multiple myeloma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

P Moreau, J San Miguel, P Sonneveld… - Annals of …, 2017 - annalsofoncology.org
Multiple myeloma (MM) accounts for 1% of all cancers and $10% of all haematological
malignancies. The incidence in Europe is 4.5–6.0/100 000/year with a median age at …

Oral ixazomib maintenance following autologous stem cell transplantation (TOURMALINE-MM3): a double-blind, randomised, placebo-controlled phase 3 trial

MA Dimopoulos, F Gay, F Schjesvold, M Beksac… - The Lancet, 2019 - thelancet.com
Background Maintenance therapy following autologous stem cell transplantation (ASCT)
can delay disease progression and prolong survival in patients with multiple myeloma …

[HTML][HTML] Chromosome 1q21 abnormalities in multiple myeloma

TM Schmidt, R Fonseca, SZ Usmani - Blood cancer journal, 2021 - nature.com
Abstract Gain of chromosome 1q (+ 1q) is one of the most common recurrent cytogenetic
abnormalities in multiple myeloma (MM), occurring in approximately 40% of newly …

Multiple myeloma: 2020 update on diagnosis, risk‐stratification and management

SV Rajkumar - American journal of hematology, 2020 - Wiley Online Library
Disease overview Multiple myeloma accounts for approximately 10% of hematologic
malignancies. Diagnosis The diagnosis requires≥ 10% clonal bone marrow plasma cells or …

[HTML][HTML] Proteasome inhibitors for the treatment of multiple myeloma

S Ito - Cancers, 2020 - mdpi.com
Use of proteasome inhibitors (PIs) has been the therapeutic backbone of myeloma treatment
over the past decade. Many PIs are being developed and evaluated in the preclinical and …