Marine bacteria are excellent yet often underexplored sources of structurally unique
bioactive natural products. In this review we cover the diversity of marine bacterial …

Nonproteinogenic amino acids are the unique building blocks of nonribosomal peptides
(NRPs) and hybrid nonribosomal peptide–polyketides (NRP–PKs) and contribute to their …

Human physiology is regulated by endogenous signalling compounds, including fatty acid
amides (FAAs), chemical mimics of which are made by bacteria. The molecules produced by …

Thiazole scaffold-based small molecules exhibit a range of biological activities and play
important roles in drug discovery. Based on bioinformatics analysis, a putative biosynthetic …

Dimethylation of amino acids consists of an interesting and puzzling series of events that
could be achieved, during nonribosomal peptide biosynthesis, either by a single adenylation …

A potent class of DNA-damaging agents, natural product bis-intercalator depsipeptides
(NPBIDs), was evaluated as ultrapotent payloads for use in antibody–drug conjugates …

MbtH‐like proteins (MLPs) are required for soluble expression and/or optimal activity of
some adenylation (A) domains of nonribosomal peptide synthetases. Because A domains …

A green electrochemical method of preparing diacid‐disulfides has been developed, in
which an S− S bond is formed by electrochemically oxidative coupling of S− H/S− H …

Minor genera actinomycetes are considered a promising source of new secondary
metabolites. The strain Kribbella sp. CA-293567 produces sandramycin and kribbellichelins …

Nature has historically served as a prolific source of biologically active molecules produced
by plants, fungi, and bacteria termed natural products (NPs). These NPs often serve as …