Summary Keratin 8 (K8) and keratin 18 (K18) are the most common and characteristic
members of the large intermediate filament gene family expressed in 'simple'or single layer …

For more than 60 years, the chemical induction of tumors in mouse skin has been used to
study mechanisms of epithelial carcinogenesis and evaluate modifying factors. In the …

The broad concept of chemoprevention applies to the prevention of clinical cancer by the
administration of chemical agents. Current approaches to the development and marketing …

Upregulation of keratinocyte-derived VEGF-A expression has recently been established in
non-neoplastic processes of skin such as wound healing, blistering diseases and psoriasis …

The proto-oncogene c-fos is a major nuclear target for signal transduction pathways
involved in the regulation of cell growth, differentiation, and transformation. Using the …

The mouse skin carcinogenesis protocol is a unique model for understanding the molecular
events leading to oncogenic transformation. Mutations in the Ha-ras gene, and the presence …

Mutations in ras and p53 are the most prevalent mutations found in human nonmelanoma
skin cancers. Although some p53 mutations cause a loss of function, most result in …

The regulatory elements of the human keratin K1 gene have been used to target expression
of the v‐Ha‐ras oncogene exclusively in the epidermis of transgenic mice. We developed 12 …

Lethal progression of prostate cancer metastasis can be improved by developing animal
models that recapitulate the clinical conditions. We report here that cytokeratin 13 (KRT13) …

Two distinct bidirectional selective breedings for quantitative traits were initiated from
identical genetically heterogeneous mouse populations. The resulting lines are …