Arsenical medicine has obtained its status in traditional Chinese medicine for more than
2,000 years. In the 1970s, arsenic trioxide was identified to have high efficacy and potency …

Ethnopharmacological relevance Processed from natural minerals, arsenic trioxide (ATO) as
an ancient Chinese medicine has been used to treat diseases for over 2000 years. And it …

Background Colorectal cancer is a highly prevalent and deadly. The most common
metastatic site is the liver. We performed a whole exome sequencing analysis of a series of …

Notch signaling, renowned for its role in regulating cell fate, organ development, and tissue
homeostasis across metazoans, is highly conserved throughout evolution. The Notch …

Arsenic has been an element of great interest among scientists for many years as it is a
widespread metalloid in our ecosystem. Arsenic is mostly recognized with negative …

Organoids, characterized by their high physiological attributes, effectively preserve the
genetic characteristics, physiological structure, and function of the simulated organs. Since …

Hedgehog (Hh) signaling plays a significant role in embryogenesis and several
physiological processes, such as wound healing and organ homeostasis. In a pathological …

Despite incessant research, colorectal cancer (CRC) is still one of the most common causes
of fatality in both men and women worldwide. Over time, advancements in medical …

Currently, cancer is still a leading cause of human death globally. Tumor deterioration
comprises multiple events including metastasis, therapeutic resistance and immune …

Gastrointestinal (GI) cancers are the most frequent neoplasm, responsible for half of all
cancer-related deaths. Metastasis is the leading cause of death from GI cancer; thus …