All RNA species in yeast cells are subject to turnover. Work over the past 20 years has
defined degradation mechanisms for messenger RNAs, transfer RNAs, ribosomal RNAs …

In all eukaryotes, nuclear DNA-dependent RNA polymerases I, II and III synthesize the
myriad RNAs that are essential for life. Remarkably, plants have evolved two additional …

Maintaining proper mRNA levels is a key aspect in the regulation of gene expression. The
balance between mRNA synthesis and decay determines these levels. We demonstrate that …

Messenger RNA decay measurements are typically performed on a population of cells.
However, this approach cannot reveal sufficient complexity to provide information on …

The purpose of this review is to provide an analysis of the latest developments on the
functions of the carbon catabolite-repression 4-Not (Ccr4-Not) complex in regulating …

Abstract mRNA concentration depends on the balance between transcription and
degradation rates. On both sides of the equilibrium, synthesis and degradation show …

Promoters are DNA elements that enable transcription and its regulation by trans-acting
factors. Here, we demonstrate that yeast promoters can also regulate mRNA decay after the …

Little is known about crosstalk between the eukaryotic transcription and translation
machineries that operate in different cell compartments. The yeast proteins Rpb4p and …

Gene expression is regulated by the rates of synthesis and degradation of mRNAs, but how
these processes are coordinated is poorly understood. Here, we show that reduced …

To maintain protein homeostasis in changing nutrient environments, cells must precisely
control the amount of their proteins, despite the accompanying changes in cell growth and …