DNA methylation is a broadly-investigated epigenetic modification that has been considered
as a heritable and reversible change. Previous findings have indicated that DNA methylation …

Despite the significant prevalence of Major Depressive Disorder in the pediatric population,
the pathophysiology of this condition remains unclear, and the treatment outcomes poor …

In recent years, escitalopram (ESC) has been suggested to have different mechanisms of
action beyond its well known selective serotonin reuptake inhibition. The aim of this study is …

The existence of a proportional relationship between the number of early-life stress (ELS)
events experienced and the impoverishment of child mental health has been hypothesized …

Background Epigenetic changes are considered the main mechanisms behind the interplay
of environment and genetic susceptibility in major depressive disorder (MDD). However …

Schizophrenia (SCZ) is a severe psychiatric and neurodevelopmental disorder. The
pathological process of SCZ starts early during development, way before the first onset of …

Background There is a growing interest in the role of brain-derived neurotrophic factor
(BDNF) in major depressive disorder (MDD). BDNF potentially exhibits opposite effects in …

Psychiatric disorders exhibit an enormous burden on the health care systems worldwide
accounting for around one-third of years lost due to disability among adults. Their etiology is …

Background Treatment-resistant depression (TRD) results in huge healthcare costs and
poor patient clinical outcomes. Most studies have adopted a “candidate mechanism” …

Electroconvulsive therapy (ECT) is a quick-acting and powerful antidepressant treatment
considered to be effective in treating severe and pharmacotherapy-resistant forms of …