Sodium glucose cotransporter 2 inhibitors in the treatment of diabetes mellitus: cardiovascular and kidney effects, potential mechanisms, and clinical applications

HJL Heerspink, BA Perkins, DH Fitchett, M Husain… - Circulation, 2016 - Am Heart Assoc
Sodium-glucose cotransporter-2 (SGLT2) inhibitors, including empagliflozin, dapagliflozin,
and canagliflozin, are now widely approved antihyperglycemic therapies. Because of their …

[HTML][HTML] Renoprotective effects of sodium-glucose cotransporter-2 inhibitors

HJL Heerspink, M Kosiborod, SE Inzucchi… - Kidney international, 2018 - Elsevier
Over the past two years, our understanding of anti-hyperglycemic medications used to treat
patients with type 2 diabetes (T2D) has fundamentally changed. Before the EMPA-REG …

Euglycemic diabetic ketoacidosis: a potential complication of treatment with sodium–glucose cotransporter 2 inhibition

AL Peters, EO Buschur, JB Buse, P Cohan… - Diabetes …, 2015 - Am Diabetes Assoc
OBJECTIVE Sodium–glucose cotransporter 2 (SGLT-2) inhibitors are the most recently
approved antihyperglycemic medications. We sought to describe their association with …

Euglycemic diabetic ketoacidosis: a predictable, detectable, and preventable safety concern with SGLT2 inhibitors.

J Rosenstock, E Ferrannini - Diabetes care, 2015 - europepmc.org
US Food and Drug Administration. Drug Safety Communication: FDA warns that SGLT2
inhibitors for diabetes may result in a serious condition of too much acid in the blood …

Empagliflozin as adjunctive to insulin therapy in type 1 diabetes: the EASE trials

J Rosenstock, J Marquard, LM Laffel… - Diabetes …, 2018 - Am Diabetes Assoc
OBJECTIVE To evaluate the safety and efficacy of empagliflozin 10-and 25-mg doses plus a
unique lower dose (2.5 mg) as adjunct to intensified insulin in patients with type 1 diabetes …

International consensus on risk management of diabetic ketoacidosis in patients with type 1 diabetes treated with sodium–glucose cotransporter (SGLT) inhibitors

T Danne, S Garg, AL Peters, JB Buse, C Mathieu… - Diabetes …, 2019 - Am Diabetes Assoc
Sodium–glucose cotransporter (SGLT) inhibitors are new oral antidiabetes medications
shown to effectively reduce glycated hemoglobin (A1C) and glycemic variability, blood …

SGLT2 inhibitors may predispose to ketoacidosis

SI Taylor, JE Blau, KI Rother - The Journal of Clinical …, 2015 - academic.oup.com
Context: Sodium glucose cotransporter 2 (SGLT2) inhibitors are antidiabetic drugs that
increase urinary excretion of glucose, thereby improving glycemic control and promoting …

Pharmacodynamics, efficacy and safety of sodium–glucose co-transporter type 2 (SGLT2) inhibitors for the treatment of type 2 diabetes mellitus

AJ Scheen - Drugs, 2015 - Springer
Inhibitors of sodium–glucose co-transporter type 2 (SGLT2) are proposed as a novel
approach for the management of type 2 diabetes mellitus (T2DM). Several compounds are …

Sodium-glucose co-transporters and their inhibition: clinical physiology

E Ferrannini - Cell metabolism, 2017 - cell.com
Sodium-glucose cotransporter-2 (SGLT2) is selectively expressed in the human kidney,
where it executes reabsorption of filtered glucose with a high capacity; it may be overactive …

SGLT2 inhibitor–associated diabetic ketoacidosis: clinical review and recommendations for prevention and diagnosis

RM Goldenberg, LD Berard, AYY Cheng, JD Gilbert… - Clinical …, 2016 - Elsevier
Purpose Sodium-glucose cotransporter 2 (SGLT2) inhibitors are the newest class of
antihyperglycemic agents available on the market. Regulator warnings and concerns …