Peroxisome proliferator-activated receptors (PPARs) are fatty acid-activated transcription
factors of nuclear hormone receptor superfamily that regulate energy metabolism. Currently …

Osteoimmunity is involved in regulating the balance of bone remodeling and resorption, and
is essential for maintaining normal bone morphology. The interaction between immune cells …

Following detection of bacteria, macrophages switch their metabolism from oxidative
respiration through the tricarboxylic acid cycle to high-rate aerobic glycolysis. This …

Aims Phagocytosis is the cellular digestion of extracellular particles, such as pathogens and
dying cells, and is a key element in the evolution of central nervous system (CNS) disorders …

Uncontrolled inflammation is a leading cause of many clinically relevant diseases. Current
therapeutic strategies focus mainly on immunosuppression rather than on the mechanisms …

Macrophages play an essential role not only in mediating the first line of defense but also in
maintaining tissue homeostasis. In response to extrinsic factors derived from a given tissue …

Inflammation is a physiological process involved in the defenses of the body and the repair
of tissues. It is acutely activated by infections, trauma, toxins, or allergic reactions. However …

Cells are richly equipped with nuclear receptors, which act as ligand-regulated transcription
factors. Peroxisome proliferator activated receptors (PPARs), members of the nuclear …

Immune cells provide defense against non‐self and have recently been shown to also play
key roles in diverse processes such as development, metabolism, and tumor progression …

Tissue-resident macrophages are key players in inflammatory processes, and their
activation and functionality are crucial in health and disease. Numerous diseases are …