Adipose tissue, colloquially known as" fat," is an extraordinarily flexible and heterogeneous
organ. While historically viewed as a passive site for energy storage, we now appreciate that …

Neurons in the central nervous system (CNS) communicate with peripheral organs largely
via the autonomic nervous system (ANS). Through such communications, the sympathetic …

Adipose tissues communicate with the central nervous system to maintain whole-body
energy homeostasis. The mainstream view is that circulating hormones secreted by the fat …

Beiging of white adipose tissue (WAT) is associated with an increase of anti-inflammatory
M2-like macrophages in WAT. However, mechanisms through which M2-like macrophages …

Sympathetic activation during cold exposure increases adipocyte thermogenesis via the
expression of mitochondrial protein uncoupling protein 1 (UCP1). The propensity of …

A healthy adipose tissue (AT) is indispensable to human wellbeing. Among other roles, it
contributes to energy homeostasis and provides insulation for internal organs. Adipocytes …

Adipocytes deficient in fatty acid synthase (iAdFASNKO) emit signals that mimic cold
exposure to enhance the appearance of thermogenic beige adipocytes in mouse inguinal …

Adult and childhood obesity have reached pandemic level proportions. The idea that caloric
excess and insufficient levels of physical activity leads to obesity is a commonly accepted …

Mitochondrial uncoupling protein 1 (UCP1) is the crucial mechanistic component of heat
production in classical brown fat and the newly identified beige or brite fat. Thermogenesis …

Inguinal white adipose tissue (iWAT) is essential for the beneficial effects of exercise training
on metabolic health. The underlying mechanisms for these effects are not fully understood …