Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …

The ascendancy of metallo-β-lactamases within the clinical sector, while not ubiquitous, has
nonetheless been dramatic; some reports indicate that nearly 30% of imipenem-resistant …

Metallo-β-Lactamases (MBLs) are class B β-lactamases that hydrolyze almost all clinically-
available β-lactam antibiotics. MBLs feature the distinctive αβ/βα sandwich fold of the …

One strategy employed by bacterial strains to resist β-lactam antibiotics is the expression of
metallo-β-lactamases requiring Zn2+ for activity. In the last few years, many new zinc β …

Gram-negative bacteria, especially Enterobacterales, have emerged as major players in
antimicrobial resistance worldwide. Resistance may affect all major classes of anti-gram …

Abstract Carbapenems,'last-resort'β-lactam antibiotics, are inactivated by zinc-dependent
metallo-β-lactamases (MBLs). The host innate immune response withholds nutrient metal …

Metallo-β-lactamases are the latest resistance mechanism of pathogenic and opportunistic
bacteria against carbapenems, considered as last resort drugs. The worldwide spread of …

Antibiotic resistance is one of the greatest public-health challenges worldwide, especially
with regard to Gram-negative bacteria (GNB). Carbapenems are the β-lactam antibiotics of …

The aim of the present study was to assess the occurrence and molecular diversity of β-
lactamase genes and integrons among Gram-negative ampicillin-resistant bacteria from Ria …

While the vast majority of our food supplies are nutritious and safe, foodborne pathogen-
related illness still affects millions of people each year. Large outbreaks of foodborne …