Pathogenicity and virulence of influenza

Y Liang - Virulence, 2023 - Taylor & Francis
Influenza viruses, including four major types (A, B, C, and D), can cause mild-to-severe and
lethal diseases in humans and animals. Influenza viruses evolve rapidly through antigenic …

An influenza A virus can evolve to use human ANP32E through altering polymerase dimerization

CM Sheppard, DH Goldhill, OC Swann, E Staller… - Nature …, 2023 - nature.com
Abstract Human ANP32A and ANP32B are essential but redundant host factors for influenza
virus genome replication. While most influenza viruses cannot replicate in edited human …

Highly pathogenic avian influenza H5N1 virus infections in wild red foxes (Vulpes vulpes) show neurotropism and adaptive virus mutations

L Bordes, S Vreman, R Heutink, M Roose… - Microbiology …, 2023 - Am Soc Microbiol
During the 2020 to 2022 epizootic of highly pathogenic avian influenza virus (HPAI), several
infections of mammalian species were reported in Europe. In the Netherlands, HPAI H5N1 …

Structures of influenza A virus RNA polymerase offer insight into viral genome replication

H Fan, AP Walker, L Carrique, JR Keown… - Nature, 2019 - nature.com
Influenza A viruses are responsible for seasonal epidemics, and pandemics can arise from
the transmission of novel zoonotic influenza A viruses to humans,. Influenza A viruses …

Zoonotic mutation of highly pathogenic avian influenza H5N1 virus identified in the brain of multiple wild carnivore species

S Vreman, M Kik, E Germeraad, R Heutink, F Harders… - Pathogens, 2023 - mdpi.com
Wild carnivore species infected with highly pathogenic avian influenza (HPAI) virus subtype
H5N1 during the 2021–2022 outbreak in the Netherlands included red fox (Vulpes vulpes) …

Characterization of H5N1 avian influenza virus isolated from bird in Russia with the E627K mutation in the PB2 protein

VY Marchenko, AS Panova, NP Kolosova… - Scientific Reports, 2024 - nature.com
Abstract Currently A (H5Nx) avian influenza viruses are globally widespread and continue to
evolve. Since their emergence in 2020 novel highly pathogenic avian influenza A (H5N1) …

Genetic diversity, phylogeography, and evolutionary dynamics of highly pathogenic avian influenza A (H5N6) viruses

J Zhang, Y Chen, N Shan, X Wang, S Lin, K Ma… - Virus …, 2020 - academic.oup.com
From 2013 onwards, the spread of novel H5N6 highly pathogenic avian influenza (HPAI)
viruses in China has posed great threats to not only poultry industry but also human health …

[HTML][HTML] The combined effect of oseltamivir and favipiravir on influenza a virus evolution in patients hospitalized with severe influenza

S Mu, X Zou, Y Wang, X Deng, D Cui, S Liu, B Cao - Antiviral Research, 2023 - Elsevier
Our previous study shows favipiravir and oseltamivir combination therapy may accelerate
clinical recovery compared to oseltamivir monotherapy in severe influenza, but its effect on …

Generation of neutralizing and non-neutralizing monoclonal antibodies against H7N9 influenza virus

F Yang, Y Xiao, R Lu, B Chen, F Liu… - Emerging Microbes & …, 2020 - Taylor & Francis
The H7N9 viruses have been circulating for six years. The insertion of a polybasic cleavage
site in the haemagglutinin (HA) protein of H7N9 has resulted in the emergence of a highly …

BAG6 inhibits influenza A virus replication by inducing viral polymerase subunit PB2 degradation and perturbing RdRp complex assembly

Y Zhou, T Li, Y Zhang, N Zhang, Y Guo, X Gao… - Plos …, 2024 - journals.plos.org
The interaction between influenza A virus (IAV) and host proteins is an important process
that greatly influences viral replication and pathogenicity. PB2 protein is a subunit of viral …