Over the past decade, comprehensive sequencing efforts have revealed the genomic
landscapes of common forms of human cancer. For most cancer types, this landscape …

The revolution in cancer research can be summed up in a single sentence: cancer is, in
essence, a genetic disease. In the last decade, many important genes responsible for the …

Individuals who smoke generally do so with the knowledge of potential consequences to
their own health. What is rarely considered are the effects of smoking on their future children …

Isogenic laboratory mouse strains enhance reproducibility because individual animals are
genetically identical. For the most widely used isogenic strain, C57BL/6, there exists a …

Our understanding of the chronology of human evolution relies on the “molecular clock”
provided by the steady accumulation of substitutions on an evolutionary lineage. Recent …

This workshop reviewed the current science to inform and recommend the best evidence-
based approaches on the use of germ cell genotoxicity tests. The workshop questions and …

Given the many levels of biological variation in mutation rates observed to date in primates-
spanning from species to individuals to genomic regions-future steps in our understanding …

After more than 80 years of searching for human germ‐cell mutagens, I think that sufficient
evidence already exists for a number of agents to be so considered, and definitive …

Understanding the effects of environmental exposures on germline mutation rates has been
a decades-long pursuit in genetics. We used next-generation sequencing and comparative …

Background The transgenic rodent mutation reporter assay provides an efficient approach to
identify mutagenic agents in vivo. A major advantage of this assay is that mutant reporter …