Circulating microRNAs in cancer: origin, function and application

R Ma, T Jiang, X Kang - Journal of experimental & clinical cancer research, 2012 - Springer
MicroRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression
at the posttranscriptional level. The dysregulation of miRNAs has been linked to a series of …

Circulating miRNAs in cancer: from detection to therapy

WT Wang, YQ Chen - Journal of hematology & oncology, 2014 - Springer
Since the discovery of circulating microRNAs (miRNAs) in body fluids, an increasing number
of studies have focused on their potential as non-invasive biomarkers and as therapeutic …

Deep sequencing of small RNAs from human skin reveals major alterations in the psoriasis miRNAome

CE Joyce, X Zhou, J Xia, C Ryan… - Human molecular …, 2011 - academic.oup.com
Psoriasis is a chronic and complex inflammatory skin disease with lesions displaying
dramatically altered mRNA expression profiles. However, much less is known about the …

miRNA expression profiling of 51 human breast cancer cell lines reveals subtype and driver mutation-specific miRNAs

M Riaz, MTM van Jaarsveld, A Hollestelle… - Breast cancer …, 2013 - Springer
Introduction Breast cancer is a genetically and phenotypically complex disease. To
understand the role of miRNAs in this molecular complexity, we performed miRNA …

Suppression of miRNA-708 by polycomb group promotes metastases by calcium-induced cell migration

S Ryu, K McDonnell, H Choi, D Gao, M Hahn, N Joshi… - Cancer cell, 2013 - cell.com
The progression of cancer to metastatic disease is a major cause of death. We identified miR-
708 being transcriptionally repressed by polycomb repressor complex 2-induced H3K27 …

Different miRNA expression profiles between human breast cancer tumors and serum

J Zhu, Z Zheng, J Wang, J Sun, P Wang, X Cheng… - Frontiers in …, 2014 - frontiersin.org
A bunch of microRNAs (miRNAs) have been demonstrated to be aberrantly expressed in
cancer tumor tissue and serum. The miRNA signatures identified from the serum samples …

A deep sequencing approach to uncover the miRNOME in the human heart

S Leptidis, H El Azzouzi, SI Lok, R de Weger… - PloS one, 2013 - journals.plos.org
MicroRNAs (miRNAs) are a class of non-coding RNAs of∼ 22 nucleotides in length, and
constitute a novel class of gene regulators by imperfect base-pairing to the 3′ UTR of …

Circulating microRNAs: potential biomarkers for common malignancies

S Khoury, N Tran - Biomarkers in medicine, 2015 - Taylor & Francis
MicroRNAs (miRNAs) belong to a class of small noncoding RNAs (ncRNAs), which regulate
gene expression at the post-transcriptional level. They are approximately 22 nucleotide …

Extracellular RNAs: development as biomarkers of human disease

JF Quinn, T Patel, D Wong, S Das… - Journal of …, 2015 - Taylor & Francis
Ten ongoing studies designed to test the possibility that extracellular RNAs may serve as
biomarkers in human disease are described. These studies, funded by the NIH Common …

Profiling cell-free and circulating miRNA: a clinical diagnostic tool for different cancers

C Chakraborty, S Das - Tumor Biology, 2016 - Springer
Effective cancer management depends on early diagnosis and treatment. There are several
microRNAs (miRNAs) which are used for detection of various cancers. Cell-free and …