Neuronal Kv7 channels underlie a voltage-gated non-inactivating potassium current known
as the M-current. Due to its particular characteristics, Kv7 channels show pronounced …

Ion channels are integral membrane proteins whose gating has been increasingly shown to
depend on the presence of the low-abundance membrane phospholipid …

KCNQ2 and KCNQ3 potassium channels have emerged as central regulators of pyramidal
neuron excitability and spiking behavior. However, despite an abundance of evidence …

Kv7 channels are enriched at the axonal plasma membrane where their voltage-dependent
potassium currents suppress neuronal excitability. Mutations in Kv7. 2 and Kv7. 3 subunits …

The gut-derived orexigenic peptide hormone ghrelin enhances neuronal firing in the
substantia nigra pars compacta, where dopaminergic neurons modulate the function of the …

A common feature of neurological and neuropsychiatric disorders is a breakdown in the
integrity of intracellular signal transduction pathways. Dysregulation of ion channels and …

Gq protein–coupled receptors (GqPCRs) of the plasma membrane activate the
phospholipase C (PLC) signaling cascade. PLC cleaves the membrane lipid …

The fidelity of neuronal signaling requires organization of signaling molecules into
macromolecular complexes, whose components are in intimate proximity. The intrinsic …

M-channel inhibitors, especially XE991, are being used increasingly in animal experiments;
however, insufficient characterization of XE991 at times confounds the interpretation of …

Transient receptor potential classical (or canonical)(TRPC) 3, TRPC6, and TRPC7 are a
subfamily of TRPC channels activated by diacylglycerol (DAG) produced through the …