Ex-vivo Kidney Machine Perfusion: Therapeutic Potential

R Zulpaite, P Miknevicius, B Leber, K Strupas… - Frontiers in …, 2021 - frontiersin.org
Kidney transplantation remains the gold standard treatment for patients suffering from end-
stage kidney disease. To meet the constantly growing organ demands grafts donated after …

[HTML][HTML] Renal normothermic machine perfusion: the road toward clinical implementation of a promising pretransplant organ assessment tool

TL Hamelink, B Ogurlu, J De Beule, VA Lantinga… - …, 2022 - journals.lww.com
The increased utilization of high-risk renal grafts for transplantation requires optimization of
pretransplant organ assessment strategies. Current decision-making methods to accept an …

Monobody adapter for functional antibody display on nanoparticles for adaptable targeted delivery applications

C Albert, L Bracaglia, A Koide, J DiRito, T Lysyy… - Nature …, 2022 - nature.com
Vascular endothelial cells (ECs) play a central role in the pathophysiology of many
diseases. The use of targeted nanoparticles (NPs) to deliver therapeutics to ECs could …

Treatment of transplant kidneys during machine perfusion

SA Hosgood, M Hoff, ML Nicholson - Transplant International, 2021 - Wiley Online Library
The increasing use of donation after circulatory death (DCD) and extended criteria donor
(ECD) organs has raised awareness of the need to improve the quality of kidneys for …

The application of nanoparticles in diagnosis and treatment of kidney diseases

P Paluszkiewicz, A Martuszewski, N Zaręba… - International Journal of …, 2021 - mdpi.com
Nanomedicine is currently showing great promise for new methods of diagnosing and
treating many diseases, particularly in kidney disease and transplantation. The unique …

[HTML][HTML] Normothermic machine perfusion (NMP) of the liver–current status and future perspectives

CJ van Beekum, TO Vilz, TR Glowka… - Annals of …, 2021 - ncbi.nlm.nih.gov
A shortage of available organs for liver transplantation has led transplant surgeons and
researchers to seek for innovative approaches in hepatoprotection and improvement of …

Gastrointestinal dysfunction criteria in critically ill children: the PODIUM consensus conference

KV Typpo, SY Irving, JM Prince, N Pathan… - Pediatrics, 2022 - publications.aap.org
CONTEXT Prior criteria to define pediatric multiple organ dysfunction syndrome (MODS) did
not include gastrointestinal dysfunction. OBJECTIVES Our objective was to evaluate current …

[HTML][HTML] Utilizing pathophysiological concepts of ischemia-reperfusion injury to design renoprotective strategies and therapeutic interventions for normothermic ex vivo …

B Ogurlu, TL Hamelink, IM Van Tricht… - American Journal of …, 2024 - Elsevier
Normothermic machine perfusion (NMP) has emerged as a promising tool for the
preservation, viability assessment, and repair of deceased-donor kidneys prior to …

Rational nanoparticle design: Optimization using insights from experiments and mathematical models

O Richfield, AS Piotrowski-Daspit, K Shin… - Journal of Controlled …, 2023 - Elsevier
Polymeric nanoparticles are highly tunable drug delivery systems that show promise in
targeting therapeutics to specific sites within the body. Rational nanoparticle design can …

D-dimer release from livers during ex situ normothermic perfusion and after in situ normothermic regional perfusion: evidence for occult fibrin burden associated with …

CJE Watson, S MacDonald, C Bridgeman… - …, 2023 - journals.lww.com
Background. Deceased donor livers are prone to biliary complications, which may
necessitate retransplantation, and we, and others, have suggested that these complications …