Identification of a gut microbiota member that ameliorates DSS-induced colitis in intestinal barrier enhanced Dusp6-deficient mice
CS Chang, YC Liao, CT Huang, CM Lin, CHY Cheung… - Cell Reports, 2021 - cell.com
Strengthening the gut epithelial barrier is a potential strategy for management of gut
microbiota-associated illnesses. Here, we demonstrate that dual-specificity phosphatase 6 …
microbiota-associated illnesses. Here, we demonstrate that dual-specificity phosphatase 6 …
Domestic animals as models for biomedical research
L Andersson - Upsala Journal of Medical Sciences, 2016 - Taylor & Francis
Domestic animals are unique models for biomedical research due to their long history
(thousands of years) of strong phenotypic selection. This process has enriched for novel …
(thousands of years) of strong phenotypic selection. This process has enriched for novel …
The ZBED6–IGF2 axis has a major effect on growth of skeletal muscle and internal organs in placental mammals
A single nucleotide substitution in the third intron of insulin-like growth factor 2 (IGF2) is
associated with increased muscle mass and reduced subcutaneous fat in domestic pigs …
associated with increased muscle mass and reduced subcutaneous fat in domestic pigs …
Free fatty acid receptor 4 deletion attenuates colitis by modulating Treg Cells via ZBED6-IL33 pathway
S Zhu, J Zhang, X Jiang, W Wang, YQ Chen - EBioMedicine, 2022 - thelancet.com
Background Inflammatory bowel disease (IBD) has complex genetic and environmental
aspects, and free fatty acid receptors (FFARs) may bridge genetic and dietary aspects …
aspects, and free fatty acid receptors (FFARs) may bridge genetic and dietary aspects …
Understanding gene regulatory mechanisms by integrating ChIP-seq and RNA-seq data: statistical solutions to biological problems
C Angelini, V Costa - Frontiers in cell and developmental biology, 2014 - frontiersin.org
The availability of omic data produced from international consortia, as well as from
worldwide laboratories, is offering the possibility both to answer long-standing questions in …
worldwide laboratories, is offering the possibility both to answer long-standing questions in …
Mesodermal iPSC–derived progenitor cells functionally regenerate cardiac and skeletal muscle
M Quattrocelli, M Swinnen… - The Journal of …, 2015 - Am Soc Clin Investig
Conditions such as muscular dystrophies (MDs) that affect both cardiac and skeletal
muscles would benefit from therapeutic strategies that enable regeneration of both of these …
muscles would benefit from therapeutic strategies that enable regeneration of both of these …
Porcine ZBED6 regulates growth of skeletal muscle and internal organs via multiple targets
ZBED6 (zinc finger BED domain containing protein 6) is a transcription factor unique to
placental mammals and its interaction with the IGF2 (insulin-like growth factor 2) locus plays …
placental mammals and its interaction with the IGF2 (insulin-like growth factor 2) locus plays …
ZBED6 counteracts high-fat diet-induced glucose intolerance by maintaining beta cell area and reducing excess mitochondrial activation
X Wang, S Younis, J Cen, Y Wang, C Krizhanovskii… - Diabetologia, 2021 - Springer
Aims/hypothesis ZBED6 (zinc finger, BED-type containing 6) is known to regulate muscle
mass by suppression of Igf2 gene transcription. In insulin-producing cell lines, ZBED6 …
mass by suppression of Igf2 gene transcription. In insulin-producing cell lines, ZBED6 …
Phosphorylation of TET2 by AMPK is indispensable in myogenic differentiation
Background TET-mediated oxidation of 5-mC participates in both passive and active DNA
demethylation, which exerts a significant influence on diverse biological processes. Mass …
demethylation, which exerts a significant influence on diverse biological processes. Mass …
Transcriptional modulator ZBED6 affects cell cycle and growth of human colorectal cancer cells
M Akhtar Ali, S Younis, O Wallerman… - Proceedings of the …, 2015 - National Acad Sciences
The transcription factor ZBED6 (zinc finger, BED-type containing 6) is a repressor of IGF2
whose action impacts development, cell proliferation, and growth in placental mammals. In …
whose action impacts development, cell proliferation, and growth in placental mammals. In …