Los anticoagulantes orales de acción directa (ACOD) son fármacos que han demostrado
tener un perfil de seguridad superior a los antivitamina K (AVK). En España la prescripción …

Purpose: To systematically review available evidence of indirect comparisons from RCTs
and direct comparisons from observational studies regarding the comparative effectiveness …

Aims To assess the association between concurrent use of potential pharmacokinetic or
pharmacodynamic interacting drugs and major bleeding among direct oral anticoagulant …

Background and Purpose: Several observational studies have compared the effect of the
non–vitamin K antagonist oral anticoagulants to each other in patients with atrial fibrillation …

Introduction In the USA, there is a steady rise of atrial fibrillation due to the aging population
with increased morbidity. This study evaluated the risk of stroke/systemic embolism (S/SE) …

Background There are no head-to-head randomized controlled trials comparing different
direct oral anticoagulants (DOACs). Thus, we systematically reviewed and meta-analyzed …

ABSTRACT Introduction: Direct oral anticoagulants (DOACs) may be regarded as some of
the most successful innovations in recent times. These drugs which were specifically …

Background: Decision making for the “best” treatment is particularly challenging in situations
in which individual patient response to drugs can largely differ from average treatment …

Direct oral anticoagulants (DOACs) are widely used for the prevention of ischemic stroke
and systemic embolism in patients with nonvalvular atrial fibrillation (NVAF). However, the …

Aims There are conflicting signals in the literature about comparative safety and
effectiveness of direct oral anticoagulants (DOACs) for nonvalvular atrial fibrillation (NVAF) …