The structure and function of olfactory receptors
Olfactory receptors (ORs) form the most important chemosensory receptor family responsible
for our sense of smell in the nasal olfactory epithelium. This receptor family belongs to the …
for our sense of smell in the nasal olfactory epithelium. This receptor family belongs to the …
[HTML][HTML] Genome-wide pan-GPCR cell libraries accelerate drug discovery
H Yang, Y Wang, W Liu, T He, J Liao, Z Qian… - … Pharmaceutica Sinica B, 2024 - Elsevier
G protein-coupled receptors (GPCRs) are pivotal in mediating diverse physiological and
pathological processes, rendering them promising targets for drug discovery. GPCRs …
pathological processes, rendering them promising targets for drug discovery. GPCRs …
Engineered odorant receptors illuminate the basis of odour discrimination
How the olfactory system detects and distinguishes odorants with diverse physicochemical
properties and molecular configurations remains poorly understood. Vertebrate animals …
properties and molecular configurations remains poorly understood. Vertebrate animals …
A pattern recognition artificial olfactory system based on human olfactory receptors and organic synaptic devices
Neuromorphic sensors, designed to emulate natural sensory systems, hold the promise of
revolutionizing data extraction by facilitating rapid and energy-efficient analysis of extensive …
revolutionizing data extraction by facilitating rapid and energy-efficient analysis of extensive …
Conserved pattern-based classification of human odorant receptor multigene family
Conserved protein-coding sequences are critical for maintaining protein function across
species. Odorant receptors (ORs), a large poorly understood multigene family responsible …
species. Odorant receptors (ORs), a large poorly understood multigene family responsible …
Calcium-Driven In Silico Inactivation of a Human Olfactory Receptor
L Pirona, F Ballabio, M Alfonso-Prieto… - Journal of Chemical …, 2024 - ACS Publications
Conformational changes as well as molecular determinants related to the activation and
inactivation of olfactory receptors are still poorly understood due to the intrinsic difficulties in …
inactivation of olfactory receptors are still poorly understood due to the intrinsic difficulties in …
Ligand discrimination in hOR1A1 based on the capacitive response
Odorant discrimination mechanisms are based on the differential interactions between
odorant molecules and olfactory receptors (ORs). Biohybrid sensors based on ORs …
odorant molecules and olfactory receptors (ORs). Biohybrid sensors based on ORs …
A status report on human odorant receptors and their allocated agonists
M Lalis, M Hladiš, S Abi Khalil, C Deroo… - Chemical …, 2024 - academic.oup.com
Olfactory perception begins when odorous substances interact with specialized receptors
located on the surface of dedicated sensory neurons. The recognition of smells depends on …
located on the surface of dedicated sensory neurons. The recognition of smells depends on …
CORD: The chordata olfactory receptor database
W Han, S Bao, J Liu, Y Wu, L Zeng, T Zhang… - Protein & …, 2024 - pubmed.ncbi.nlm.nih.gov
CORD: The chordata olfactory receptor database CORD: The chordata olfactory receptor
database Protein Cell. 2024 Sep 20:pwae050. doi: 10.1093/procel/pwae050. Online ahead of …
database Protein Cell. 2024 Sep 20:pwae050. doi: 10.1093/procel/pwae050. Online ahead of …
Synthesis, biological activity, X-ray crystallographic, molecular docking and molecular dynamics simulation studies of pyrazole-1, 3, 5-triazine derivatives as potential …
XY Xue, M Wei, Z Zhao, L Xu, Y Cao, S Chen… - Journal of Molecular …, 2024 - Elsevier
ABSTRACT Thirteen novel pyrazole-1, 3, 5-triazine derivatives were synthesized and
assessed for their potential as cholinesterase inhibitors. The structure of the compounds was …
assessed for their potential as cholinesterase inhibitors. The structure of the compounds was …