Pesticides are unique environmental contaminants that are specifically introduced into the
environment to control pests, often by killing them. Although pesticide application serves …

The numbers of potential neurotoxicants in the environment are raising and pose a great risk
for humans and the environment. Currently neurotoxicity assessment is mostly performed to …

Structural and transcriptional changes during early brain maturation follow fixed
developmental programs defined by genetics. However, whether this is true for functional …

Multiple non-animal-based test methods have never been formally validated. In order to use
such new approach methods (NAMs) in a regulatory context, criteria to define their …

Human pluripotent stem cell (hPSC)-derived neurons provide exciting opportunities for in
vitro modeling of neurological diseases and for advancing drug development and …

Neurotoxicity testing still relies on ethically debated, expensive and time consuming in vivo
experiments, which are unsuitable for high-throughput toxicity screening. There is thus a …

Functional evaluation assays using human induced pluripotent stem cell (hiPSC)-derived
neurons can predict the convulsion toxicity of new drugs and the neurological effects of …

Concerns about the neurotoxic potential of polyfluoroalkyl substances (PFAS) such as
perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) increase, although …

The brain is the most complex organ in the body, controlling our highest functions, as well as
regulating myriad processes which incorporate the entire physiological system. The effects …

The use of new psychoactive substances (NPS) is increasing and currently> 600 NPS have
been reported. However, limited information on neuropharmacological and toxicological …