The HIV-1 capsid, composed of approximately 1,200 copies of the capsid protein, encases
genomic RNA alongside viral nucleocapsid, reverse transcriptase, and integrase proteins …

HIV-1 encounters the hierarchically organized host chromatin to stably integrate and persist
in anatomically distinct latent reservoirs. The contribution of genome organization in HIV-1 …

Lentiviral DNA integration favors transcriptionally active chromatin. We previously showed
that the interaction of human immunodeficiency virus type 1 (HIV-1) capsid with cleavage …

Human immunodeficiency virus type 1 (HIV-1) capsid binds host proteins during infection,
including cleavage and polyadenylation specificity factor 6 (CPSF6) and cyclophilin A …

The cone-shaped mature HIV-1 capsid is the main orchestrator of early viral replication. After
cytosolic entry, it transports the viral replication complex along microtubules toward the …

The relationship between spatiotemporal distribution of HIV-1 proviruses and their
transcriptional activity is not well understood. To elucidate the intranuclear positions of …

Resting CD4 T cells resist productive HIV-1 infection. The HIV-2/simian immunodeficiency
virus protein viral accessory protein X (Vpx) renders these cells permissive to infection …

Herpes simplex virus type I (HSV-1) infection leads to RNA polymerase II (RNAPII)
degradation and host transcription shutdown. We show that ICP22 defines the virus-induced …

ABSTRACT GSK878 is a newly described HIV-1 inhibitor that binds to the mature capsid
(CA) hexamer in a pocket originally identified as the binding site of the well-studied CA …

Apolipoprotein B mRNA editing enzyme catalytic subunit 3 (APOBEC3) proteins are critical
for the control of infection by retroviruses. These proteins deaminate cytidines in negative …