Crohn's disease and ulcerative colitis are two idiopathic inflammatory bowel disorders. In
this paper we discuss the current diagnostic approach, their pathology, natural course, and …

Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal
tract, which includes Crohn's disease (CD) and ulcerative colitis (UC). These diseases have …

The chronic inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis, are
recognized as important causes of gastrointestinal disease in children and adults. In this …

AGA technical review on perianal Crohn’s disease - ScienceDirect Skip to main contentSkip to
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Despite its history as a human teratogen, thalidomide is emerging as a treatment for cancer
and inflammatory diseases. Although the evolution of its clinical application could not have …

Infliximab, the chimeric monoclonal immunoglobulin (Ig) G1 antibody to tumor necrosis
factor (TNF) has changed our therapy of Crohn's disease. Infliximab is indicated in refractory …

Treatment options for inflammatory bowel disease (IBD) reflect a continuing shift from
empiricism to strategies based on improved understanding of the pathophysiology of …

Tumor necrosis factor (TNF) was originally described as a protein factor capable of killing
tumor cells in vitro and causing hemorrhagic necrosis of transplantable tumors in mice. 1, 2 …

Background: Thalidomide has a chiral centre, and the racemate of (R)-and (S)-thalidomide
was introduced as a sedative drug in the late 1950s. In 1961, it was withdrawn due to …

Advancing knowledge regarding the biology of chronic inflammation has led to the
development of specific biologic therapies that mechanistically target individual …