As much as the cellular viability is important for the living organisms, the elimination of
unnecessary or damaged cells has the opposite necessity for the maintenance of …

Acute myeloid leukemia (AML) is the most commonly diagnosed leukemia in adults (25%)
and comprises 15–20% in children. It is a genetically heterogeneous aggressive disease …

Resveratrol, found in variety of plants, is a natural stilbene structure polyphenol. It has
various pharmacological effects, such as antioxidation, anti-aging, anti-inflammation, anti …

The bioactive sphingolipids including, ceramide, sphingosine, and sphingosine-1-
phosphate (S1P) have important roles in several types of signaling and regulation of many …

In recent years, the interest in natural compounds exerting immunoregulatory effects has
enormously increased. Among these, the polyphenol resveratrol, found in a variety of foods …

The role of sphingolipids as bioactive signaling molecules that can regulate cell fate
decisions puts them at center stage for cancer treatment and prevention. While ceramide …

Polyphenols, chemically characterized by a polyhydroxylated phenolic structure, are well
known for their widespread pharmacological properties: anti-inflammatory, antibiotic …

Gastric cancer (GC) is the fourth most common cancer and the second leading cause of
cancer-related mortality in the world. Late diagnosis and classical therapeutic approaches …

Sphingolipids are a wide family of lipids that share common sphingoid backbones, including
(2S, 3R)-2-amino-4-octadecane-1, 3-diol (dihydrosphingosine) and (2S, 3R, 4E)-2-amino-4 …

Sphingolipids are bioactive lipids that participate in a wide variety of biological mechanisms,
including cell death and proliferation. The myriad of pro-death and pro-survival cellular …