Medicinal chemists continue to be fascinated by chalcone derivatives because of their
simple chemistry, ease of hydrogen atom manipulation, straightforward synthesis, and a …

In an attempt to explore novel and more potent antileishmanial compounds to diversify the
current inhibitors, we pursued a medicinal chemistry-driven strategy to synthesize novel …

Leishmaniasis is one of the major neglected tropical diseases in the world and it is
considered endemic in 88 countries. This disease is transmitted by a Leishmania spp …

Visceral leishmaniasis (VL) is a neglected tropical disease that mainly affects the poor
population of the Indian, African, and South American subcontinent. The increasing …

Twenty-six Biginelli adducts were synthesized through an ionic liquid-assisted synthesis
with up to 92% yield. Sixteen of these Biginelli adducts were then assayed to determine their …

Cynaroside, a flavonoid, has been shown to have antibacterial, antifungal and anticancer
activities. Here, we evaluated its antileishmanial properties and its mechanism of action …

New Biginelli adducts were rationalised, via the introduction of selected anti-tubercular (TB)
pharmacophores into the dihydropyrimidine (DHPM) ring of deoxythymidine …

The potential of chitosan microparticles as a carrier of doxorubicin for the treatment of
visceral leishmaniasis was evaluated by macrophage-mediated drug targeting approach …

Background: A lizard Leishmania has been isolated from a lizard (Agama agilis) in Iran. Its
genome sequence has not been determined, so far. Methods: The study was done at Shahid …

Leishmania is a parasitic protozoon responsible for the neglected tropical disease
Leishmaniasis. Approximately, 350 million people are susceptible and close to 70,000 death …