G protein-coupled receptors (GPCRs) are historically the most successful family of drug
targets. In recent times it has become clear that the pharmacology of these receptors is far …

Therapeutic approaches to the treatment of type 2 diabetes mellitus that are designed to
increase insulin secretion either directly target β-cells or indirectly target gastrointestinal …

Hormone-secreting cells within pancreatic islets of Langerhans play important roles in
metabolic homeostasis and disease. However, their transcriptional characterization is still …

Background Diabetes mellitus is characterized by loss or dysfunction of insulin-producing β-
cells in the pancreas, resulting in failure of blood glucose regulation and devastating …

Emerging evidence suggests that n-3 polyunsaturated fatty acids (PUFA) promote brown
adipose tissue thermogenesis. However, the underlying mechanisms remain elusive. Here …

Fatty acid (FA)-stimulated insulin secretion (FASIS) is reviewed here in contrast to type 2
diabetes etiology, resulting from FA overload, oxidative stress, intermediate …

Omega-3 polyunsaturated fatty acids (n-3 PUFAs), which are plentiful in fish oil, have been
known for decades to be beneficial functional nutrients in different disease states. GPR120 …

Hyperreactive platelets are commonly observed in diabetic patients indicating a potential
link between glucose homeostasis and platelet reactivity. This raises the possibility that …

Patients with well-controlled low-density lipoprotein cholesterol levels, but persistent high
triglycerides, remain at increased risk for cardiovascular events as evidenced by multiple …

Abstract Family of Free Fatty Acid Receptors (FFARs), specific G protein-coupled receptors
comprises of four members: FFAR1-4, where each responds to different chain length of fatty …