Dysfunction of the mesocorticolimbic dopaminergic reward system is a core feature of
schizophrenia (SZ), yet its precise contributions to different stages of reward processing and …

The fight against neurodegenerative diseases, Alzheimer disease and Parkinson's disease
(PD), is a challenge of the 21st century. The low efficacy of treating patients is due to the late …

Importance Abnormal reward processing is suggested to underlie the formation of psychotic
symptoms, likely driven by elevated ventral striatal (VS) dopamine levels. Functional …

Anhedonia is a prominent symptom in neuropsychiatric disorders, most markedly in major
depressive disorder (MDD) and schizophrenia (SZ). Emerging evidence indicates an …

Abstract Purpose of Review Anhedonia, traditionally defined as a diminished capacity to
experience pleasure, has long been considered a core symptom of schizophrenia. However …

Reward processing impairments have been linked with positive and negative symptoms of
schizophrenia. Here, we performed a coordinate-based meta-analysis that combined eleven …

Background Abnormal reward functioning is central to anhedonia and amotivation
symptoms of schizophrenia (SCZ). Reward processing encompasses a series of …

Emerging evidence indicates that treatment context profoundly affects
psychopharmacological interventions. We review the evidence for the interaction between …

Dysfunction of reward‐related neural circuitry in schizophrenia (SCZ) has been widely
reported, and may provide insight into the motivational and cognitive disturbances that …

The polygenic architecture of schizophrenia implicates several molecular pathways involved
in synaptic function. However, it is unclear how polygenic risk funnels through these …