Adult neurogenesis, the process by which neurons are generated in certain areas of the
adult brain, declines in an age-dependent manner and is one potential target for extending …

The key hallmark of stem cells is their ability to self-renew while keeping a differentiation
potential. Intrinsic and extrinsic cell factors may contribute to a decline in these stem cell …

Insulin-dependent diabetes is a complex multifactorial disorder characterized by loss or
dysfunction of β-cells. Pancreatic β-cells differ in size, glucose responsiveness, insulin …

The application of primary organoid cultures containing epithelial and mesenchymal
elements to cancer modeling holds promise for combining the accurate multilineage …

It has generally proven challenging to produce functional β cells in vitro. Here, we describe a
previously unidentified protein C receptor positive (Procr+) cell population in adult mouse …

Lipid metabolism is fundamental for brain development and function, but its roles in normal
and pathological neural stem cell (NSC) regulation remain largely unexplored. Here, we …

Lgr5 marks adult stem cells in multiple adult organs and is a receptor for the Wnt‐agonistic R‐
spondins (RSPOs). Intestinal, stomach and liver Lgr5+ stem cells grow in 3D cultures to form …

Postnatal maintenance or regeneration of pancreatic beta cells is considered to occur
exclusively via the replication of existing beta cells, but clinically meaningful restoration of …

In the context of a cellular therapy for diabetes, methods for pancreatic progenitor expansion
and subsequent differentiation into insulin-producing beta cells would be extremely …

Although β-cell heterogeneity was discovered more than 50 years ago, the underlying
principles have been explored only during the past decade. Islet-cell heterogeneity arises …