The Changing Epidemiology of Clostridium difficile Infections
The epidemiology of Clostridium difficile infection (CDI) has changed dramatically during
this millennium. Infection rates have increased markedly in most countries with detailed …
this millennium. Infection rates have increased markedly in most countries with detailed …
Interactions Between the Gastrointestinal Microbiome and Clostridium difficile
CM Theriot, VB Young - Annual review of microbiology, 2015 - annualreviews.org
Antibiotics have significant and long-lasting effects on the intestinal microbiota and
consequently reduce colonization resistance against pathogens, including Clostridium …
consequently reduce colonization resistance against pathogens, including Clostridium …
Enterococci enhance Clostridioides difficile pathogenesis
Enteric pathogens are exposed to a dynamic polymicrobial environment in the
gastrointestinal tract. This microbial community has been shown to be important during …
gastrointestinal tract. This microbial community has been shown to be important during …
Dietary trehalose enhances virulence of epidemic Clostridium difficile
Clostridium difficile disease has recently increased to become a dominant nosocomial
pathogen in North America and Europe, although little is known about what has driven this …
pathogen in North America and Europe, although little is known about what has driven this …
Diverse Sources of C. difficile Infection Identified on Whole-Genome Sequencing
Background It has been thought that Clostridium difficile infection is transmitted
predominantly within health care settings. However, endemic spread has hampered …
predominantly within health care settings. However, endemic spread has hampered …
Emergence and global spread of epidemic healthcare-associated Clostridium difficile
M He, F Miyajima, P Roberts, L Ellison, DJ Pickard… - Nature …, 2013 - nature.com
Abstract Epidemic C. difficile (027/BI/NAP1) has rapidly emerged in the past decade as the
leading cause of antibiotic-associated diarrhea worldwide. However, the key events in …
leading cause of antibiotic-associated diarrhea worldwide. However, the key events in …
Targeted Restoration of the Intestinal Microbiota with a Simple, Defined Bacteriotherapy Resolves Relapsing Clostridium difficile Disease in Mice
Relapsing C. difficile disease in humans is linked to a pathological imbalance within the
intestinal microbiota, termed dysbiosis, which remains poorly understood. We show that …
intestinal microbiota, termed dysbiosis, which remains poorly understood. We show that …
Dietary zinc alters the microbiota and decreases resistance to Clostridium difficile infection
JP Zackular, JL Moore, AT Jordan, LJ Juttukonda… - Nature medicine, 2016 - nature.com
Clostridium difficile is the most commonly reported nosocomial pathogen in the United
States and is an urgent public health concern worldwide. Over the past decade, incidence …
States and is an urgent public health concern worldwide. Over the past decade, incidence …
Current Status of Clostridium difficile Infection Epidemiology
FC Lessa, CV Gould… - Clinical Infectious Diseases, 2012 - academic.oup.com
The dramatic changes in the epidemiology of Clostridium difficile infection (CDI) during
recent years, with increases in incidence and severity of disease in several countries, have …
recent years, with increases in incidence and severity of disease in several countries, have …
Diversity and evolution in the genome of Clostridium difficile
DR Knight, B Elliott, BJ Chang… - Clinical microbiology …, 2015 - Am Soc Microbiol
Clostridium difficile infection (CDI) is the leading cause of antimicrobial and health care-
associated diarrhea in humans, presenting a significant burden to global health care …
associated diarrhea in humans, presenting a significant burden to global health care …