Oral anticoagulation has been limited to vitamin K antagonists (VKAs) for over 60 years.
VKAs are effective and recommended for the prevention of venous and arterial …

Genotype‐guided warfarin dosing algorithms are a rational approach to optimize warfarin
dosing and potentially reduce adverse drug events. Diverse populations, such as African …

Background The cost of genomic information has fallen steeply, but the clinical translation of
genetic risk estimates remains unclear. We aimed to undertake an integrated analysis of a …

The objective of this study was to determine whether, in African‐American patients,
additional vitamin K oxidoreductase complex subunit 1 (VKORC1), cytochrome P450 2C9 …

Aims: CYP4F2* 3 (p. V433M) has been associated with higher warfarin dose requirements;
however, its frequency, like other CYP2C9 and VKORC1 variants, has not been …

Warfarin is a commonly used anticoagulant, whose dose needs to be determined for each
individual patient owing to large inter-individual variability in its therapeutic dose. Although …

Determining the optimal dose of warfarin for frail elderly patients is a challenging task
because of the low dose requirements in such patients, the wide interindividual variability of …

Methods DNA was extracted from 207 patients taking warfarin for more than 2 months and
genotyped for VKORC1 (3673 G> A), CYP2C9* 2* 3* 4* 5* 8, CYP4F2 (V33M; rs2108622) …

The aim of the study is to improve our understanding of the worldwide allele frequency
distribution of four genetic polymorphisms known to influence warfarin dosing (VKORC1 …

A systematic review and a meta‐analysis were performed to quantify the accumulated
information from genetic association studies investigating the impact of the CYP4F2 …