Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

Interleukin-7 (IL-7), a molecule known for its growth-promoting effects on progenitors of B
cells, remains one of the most extensively studied cytokines. It plays a vital role in health …

Almost 30 years ago it was first appreciated that anti-apoptotic B-cell lymphoma-2 (BCL-2)
prevents the induction of apoptosis not only in malignant cells, but also in normal cellular …

Abstract MCL1 (myeloid cell leukemia-1) is a widely recognized pro-survival member of the
Bcl-2 (B-cell lymphoma protein 2) family and a promising target for cancer therapy. While the …

Abstract MCL-1, an anti-apoptotic BCL-2 family member that is essential for the survival of
multiple cell lineages, is also among the most highly amplified genes in cancer. Although …

The development of T cells in the thymus involves several differentiation and proliferation
events, during which hematopoietic precursors give rise to T cells ready to respond to …

Blockade of the checkpoint inhibitor programmed death 1 (PD1) has demonstrated
remarkable success in the clinic for the treatment of cancer; however, a majority of tumors …

MCL-1 is an essential BCL-2 family member that promotes the survival of multiple cellular
lineages, but its role in cardiac muscle has remained unclear. Here, we report that cardiac …

After their development in the thymus, mature T cells are maintained in the periphery by two
sets of survival signals, namely TCR signals from contact with self-peptide/MHC ligands and …

BCL-2 molecules are regulators of programmed cell death and defects in this pathway
contribute to human diseases. One family member, MCL-1, is unique because its expression …