The journey of embryonic development starts at oocyte fertilization, which triggers a complex
cascade of events and cellular pathways that guide early embryogenesis. Recent …

At the beginning of mammalian life, the genetic material from each parent meets when the
fertilized egg divides. It was previously thought that a single microtubule spindle is …

Ploidy or genome‐wide chromosomal anomalies such as triploidy, diploid/triploid
mixoploidy, chimerism, and genome‐wide uniparental disomy are the cause of molar …

During human embryonic development, early cleavage-stage embryos are more susceptible
to errors. Studies have shown that many problems occur during the first mitosis, such as …

Background During normal zygotic division, two haploid parental genomes replicate, unite
and segregate into two biparental diploid blastomeres. Results Contrary to this fundamental …

Some human preimplantation embryos are chromosomally mosaic. For technical reasons,
estimates of the overall frequency vary widely from< 15 to> 90% and the true frequency …

Abstract Although Theodor Boveri linked abnormal chromosome numbers and disease more
than a century ago, an in-depth understanding of the impact of mitotic and meiotic …

While chromosomal mosaicism in the embryo was observed already in the '90s using both
karyotyping and FISH technologies, the full extent of this phenomenon and the overall …

Cells with high ploidy content are common in mammalian extraembryonic and adult tissues.
Cell-to-cell fusion generates polyploid cells during mammalian development and tissue …

Dear Editor-in-Chief: The article by Reichmann and colleagues recently published in
Science [1] raises a number of issues regarding the earliest stages of mammalian embryo …