Vitamins B9 (folate) and B12 are essential water-soluble vitamins that play a crucial role in
the maintenance of one-carbon metabolism: a set of interconnected biochemical pathways …

Abstract Methyl-Cobalamin (Cbl) derives from dietary vitamin B12 and acts as a cofactor of
methionine synthase (MS) in mammals. MS encoded by MTR catalyzes the remethylation of …

RBM10 is a nuclear RNA-binding protein (RBP) that regulates the alternative splicing of
primary transcripts. Recently, research on RBM10 has become increasingly active owing to …

Sirtuin1 (Sirt1) has a NAD (+) binding domain and modulates the acetylation status of
peroxisome proliferator-activated receptor-γ coactivator-1α (PGC1α) and Fork Head Box O1 …

Inherited disorders of B 12 metabolism produce a broad spectrum of manifestations, with
limited knowledge of the influence of age and the function of related genes. We report a …

Sirtuins, a class III histone/protein deacetylase, is a central regulator of metabolic function
and cellular stress response. This plays a pivotal role in the pathogenesis and progression …

Arrhythmogenic cardiomyopathy (ACM) is characterized by life-threatening ventricular
arrhythmias and sudden cardiac death and affects hundreds of thousands of patients …

The metabolism of sulfur-containing amino acids (SAAs) requires an orchestrated interplay
among several dozen enzymes and transporters, and an adequate dietary intake of …

Cobalamin C (cblC) deficiency, the most common inborn error of intracellular cobalamin
metabolism, is caused by mutations in MMACHC, a gene responsible for the processing and …

Aims Cognitive dysfunction associated with chronic pain may be caused by impaired
synaptic plasticity. Considering the impact of silent information regulator 1 (SIRT1) on …