Free radicals are generated in the brain, as well as in other organs, and their production is
proportional to the brain activity. Due to its low antioxidant capacity, the brain is particularly …

Despite continuous advances in understanding the underlying pathogenesis of
hyperexcitable networks and lowered seizure thresholds, the treatment of epilepsy remains …

Epilepsy is a group of chronic neurological disorders characterized by recurrent,
spontaneous, and unpredictable seizures. It is one of the most common neurological …

Neuroinflammation is thought to contribute to the pathogenesis and maintenance of
temporal lobe epilepsy, but the underlying cell and molecular mechanisms are not fully …

P2X7 receptor is an ATP-gated cation channel that upon agonist interaction leads to cellular
influx of Na+ and Ca 2+ and efflux of K+. P2X7 is expressed by a wide variety of cells and its …

Despite the progress made in the development of new antiepileptic drugs (AEDs), the
biggest challenges that epilepsy presents to drug development have remained unchanged …

The ATP-gated ionotropic P2X7 receptor (P2X7R) modulates glial activation, cytokine
production and neurotransmitter release following brain injury. Levels of the P2X7R are …

Epilepsy is one of the most common and disabling chronic neurological diseases affecting
people of all ages. Major challenges of epilepsy management include the persistently high …

Ceftriaxone is a beta-lactam antibiotic that increases the expression of the major glutamate
transporter, GLT-1. As such, ceftriaxone ameliorates symptoms across multiple rodent …

Much progress has been made over the last few decades in the identification of new anti-
epileptic drugs (AEDs). However, 30% of epilepsy patients suffer poor seizure control. This …