Cyclin-dependent kinase 2 inhibitors in cancer therapy: an update
Cyclin-dependent kinase 2 (CDK2) drives the progression of cells into the S-and M-phases
of the cell cycle. CDK2 activity is largely dispensable for normal development, but it is …
of the cell cycle. CDK2 activity is largely dispensable for normal development, but it is …
Recent Progress in the Pharmacology of Imidazo [1, 2-a] pyridines
C Enguehard-Gueiffier… - Mini Reviews in Medicinal …, 2007 - ingentaconnect.com
Imidazo [1, 2-a] pyridine is a bicyclic system with a bridgehead nitrogen atom, of growing
interest in medicinal chemistry. The paper deals with the recent progress realised in the …
interest in medicinal chemistry. The paper deals with the recent progress realised in the …
Recent developments in the synthesis of imidazo [1, 2-a] pyridines
Advances in the last decade for the synthesis of the imidazo [1, 2-a] pyridine scaffold from
various substrates employing approaches such as multicomponent reactions, tandem …
various substrates employing approaches such as multicomponent reactions, tandem …
Design, synthesis and in vitro antimicrobial evaluation of novel Imidazo [1, 2-a] pyridine and imidazo [2, 1-b][1, 3] benzothiazole motifs
New antimicrobial agents, imidazo [1, 2-a] pyridine and imidazo [2, 1-b][1, 3] benzothiazole,
have been synthesized. Their antimicrobial activities were conducted against various Gram …
have been synthesized. Their antimicrobial activities were conducted against various Gram …
Experimental and theoretical study of new Schiff bases based on imidazo (1, 2-a) pyridine as corrosion inhibitor of mild steel in 1M HCl
In this work, we report a study on the synthesis and characterization, using several
spectroscopic techniques such as IR, 13C NMR, 1H NMR and mass spectroscopy, of a new …
spectroscopic techniques such as IR, 13C NMR, 1H NMR and mass spectroscopy, of a new …
Visible-light-induced regioselective sulfenylation of imidazopyridines with thiols under transition metal-free conditions
A metal-free visible-light-promoted regioselective C-3 sulfenylation of imidazo [1, 2-a]
pyridines and indoles using thiols has been developed via C (sp2)–H functionalization. This …
pyridines and indoles using thiols has been developed via C (sp2)–H functionalization. This …
Rhodium (II) acetate-catalyzed stereoselective synthesis, SAR and anti-HIV activity of novel oxindoles bearing cyclopropane ring
G Kumari, M Modi, SK Gupta, RK Singh - European journal of medicinal …, 2011 - Elsevier
Novel oxindole derivatives bearing substituted cyclopropane ring have been designed on
the basis of docking studies with HIV-1 RT using the software DS 2.5 and synthesized as …
the basis of docking studies with HIV-1 RT using the software DS 2.5 and synthesized as …
Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase
AN Bullock, JÉ Debreczeni, OY Fedorov… - Journal of medicinal …, 2005 - ACS Publications
The kinase PIM-1 plays a pivotal role in cytokine signaling and is implicated in the
development of a number of tumors. The three-dimensional structure of PIM-1 is …
development of a number of tumors. The three-dimensional structure of PIM-1 is …
Imidazopyridine-based kinase inhibitors as potential anticancer agents: A review
Considering the fundamental role of protein kinases in the mechanism of protein
phosphorylation in critical cellular processes, their dysregulation, especially in cancers, has …
phosphorylation in critical cellular processes, their dysregulation, especially in cancers, has …
Multicomponent synthesis of imidazo [1, 2-a] pyridines using catalytic zinc chloride
AL Rousseau, P Matlaba, CJ Parkinson - Tetrahedron letters, 2007 - Elsevier
The novel use of zinc chloride to catalyze the one-pot, three component synthesis of imidazo
[1, 2-a] pyridines from a range of substrates using either conventional heating or microwave …
[1, 2-a] pyridines from a range of substrates using either conventional heating or microwave …