Advances in gelatin bioinks to optimize bioprinted cell functions

S Asim, TA Tabish, U Liaqat, IT Ozbolat… - Advanced Healthcare …, 2023 - Wiley Online Library
Gelatin is a widely utilized bioprinting biomaterial due to its cell‐adhesive and enzymatically
cleavable properties, which improve cell adhesion and growth. Gelatin is often covalently …

Extracellular matrix mechanobiology in cancer cell migration

J Vasudevan, K Jiang, JG Fernandez, CT Lim - Acta biomaterialia, 2023 - Elsevier
The extracellular matrix (ECM) is pivotal in modulating tumor progression. Besides
chemically stimulating tumor cells, it also offers physical support that orchestrates the …

Multifunctional silk fibroin methacryloyl microneedle for diabetic wound healing

G Guan, Q Zhang, Z Jiang, J Liu, J Wan, P Jin, Q Lv - Small, 2022 - Wiley Online Library
Diabetic wound is one of the common complications in diabetic patients, which exhibits
chronic, hard‐to‐heal characteristics. The healing process of wounds is impaired by several …

Digital Light Processing 3D Bioprinting of Gelatin‐Norbornene Hydrogel for Enhanced Vascularization

VT Duong, CC Lin - Macromolecular Bioscience, 2023 - Wiley Online Library
Digital light processing (DLP) bioprinting can be used to fabricate volumetric scaffolds with
intricate internal structures, such as perfusable vascular channels. The successful …

[HTML][HTML] Viscoelastic hydrogels for interrogating pancreatic cancer-stromal cell interactions

FY Lin, CY Chang, H Nguyen, H Li, ML Fishel… - Materials Today Bio, 2023 - Elsevier
The tumor microenvironment (TME) is known to direct cancer cell growth, migration, invasion
into the matrix and distant tissues, and to confer drug resistance in cancer cells. While …

Dual functionalization of gelatin for orthogonal and dynamic hydrogel cross-linking

MH Kim, H Nguyen, CY Chang… - ACS biomaterials science …, 2021 - ACS Publications
Gelatin-based hydrogels are widely used in biomedical fields because of their abundance of
bioactive motifs that support cell adhesion and matrix remodeling. Although inherently …

Viscoelastic stiffening of gelatin hydrogels for dynamic culture of pancreatic cancer spheroids

HD Nguyen, CC Lin - Acta Biomaterialia, 2024 - Elsevier
The tumor microenvironment (TME) in pancreatic adenocarcinoma (PDAC) is a complex
milieu of cellular and non-cellular components. Pancreatic cancer cells (PCC) and cancer …

Exploring New Dimensions of Tumor Heterogeneity: The Application of Single Cell Analysis to Organoid‐Based 3D In Vitro Models

N Landon‐Brace, NT Li… - Advanced Healthcare …, 2023 - Wiley Online Library
Modeling the heterogeneity of the tumor microenvironment (TME) in vitro is essential to
investigating fundamental cancer biology and developing novel treatment strategies that …

[HTML][HTML] Recent updates in click and computational chemistry for drug discovery and development

JH Cai, XZ Zhu, PY Guo, P Rose, XT Liu, X Liu… - Frontiers in …, 2023 - frontiersin.org
Drug discovery is a costly and time-consuming process with a very high failure rate.
Recently, click chemistry and computer-aided drug design (CADD) represent popular areas …

[HTML][HTML] Enhancing anti-tumor potential: low-intensity vibration suppresses osteosarcoma progression and augments MSCs' tumor-suppressive abilities

X Xiong, Q Huo, K Li, C Cui, C Chang, C Park… - Theranostics, 2024 - ncbi.nlm.nih.gov
Abstract Rationale: Osteosarcoma (OS), a common malignant bone tumor, calls for the
investigation of novel treatment strategies. Low-intensity vibration (LIV) presents itself as a …