Glycogen storage diseases (GSDs) are a group of 19 hereditary diseases caused by a lack
of one or more enzymes involved in the synthesis or degradation of glycogen and are …

Metformin has garnered considerable interest as a chemo-preventive and chemo-
therapeutic agent given the increased risk of liver cancer among diabetic patients. This work …

Energy stress is an unfavorable condition that tumor cells are often exposed to. Ferroptosis
is considered an emerging target for tumor therapy. However, the role of ferroptosis in …

Inflammation of adipose tissue in obesity is associated with increased IL-1β, IL-6 and TNF-α
secretion and proposed to contribute to insulin resistance. AMP-activated protein kinase …

Adenosine 5′-monophosphate–activated protein kinase (AMPK) is a pivotal regulator of
metabolism at cellular and organismal levels. AMPK also suppresses inflammation. We …

To discover small-molecule cancer immunotherapy candidates through targeting
Indoleamine 2, 3-dioxygenase 1 (IDO1), twenty–five new berberine (BBR) derivatives …

Signal transducer and activator of transcription 3 (STAT3) is implicated in inflammation
processing, but the mechanism of its regulation mostly remains limited to Janus kinase (JAK) …

Acute pancreatitis (AP) is a highly fatal acute inflammation and is often accompanied by
multiple organ dysfunction syndrome (MODS). The liver, one of the most vulnerable …

Glioblastoma (GBM) is the most common and malignant type of primary brain tumor and
associated with a devastating prognosis. Signal transducer and activator of transcription …

Exaggerated Janus kinase-signal transducer and activator of transcription (JAK-STAT)
signalling is key to the pathogenesis of pro-inflammatory disorders, such as rheumatoid …