Light in gold catalysis

S Witzel, ASK Hashmi, J Xie - Chemical Reviews, 2021 - ACS Publications
Within the wide family of gold-catalyzed reactions, gold photocatalysis intrinsically features
unique elementary steps. When gold catalysis meets photocatalysis, a valence change of …

Tripterygium wilfordii: An inspiring resource for rheumatoid arthritis treatment

Y Zhang, X Mao, W Li, W Chen, X Wang… - Medicinal research …, 2021 - Wiley Online Library
Abstract Tripterygium wilfordii Hook F (TwHF)‐based therapy is among the most efficient and
crucial therapeutics for the treatment of rheumatoid arthritis (RA), which indicates that TwHF …

Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-ΙΙ

J Cai, M Yi, Y Tan, X Li, G Li, Z Zeng, W Xiong… - Journal of Experimental …, 2021 - Springer
Background Pyroptosis is a lytic cell death form executed by gasdermins family proteins.
Induction of tumor pyroptosis promotes anti-tumor immunity and is a potential cancer …

HSP70 multi-functionality in cancer

Z Albakova, GA Armeev, LM Kanevskiy, EI Kovalenko… - Cells, 2020 - mdpi.com
The 70-kDa heat shock proteins (HSP70s) are abundantly present in cancer, providing
malignant cells selective advantage by suppressing multiple apoptotic pathways, regulating …

Triptolide and its derivatives as cancer therapies

P Noel, DD Von Hoff, AK Saluja, M Velagapudi… - Trends in …, 2019 - cell.com
Triptolide, a compound isolated from a Chinese medicinal herb, possesses potent antitumor,
immunosuppressive, and anti-inflammatory properties, but is clinically limited due to its poor …

Heat shock factors: integrators of cell stress, development and lifespan

M Åkerfelt, RI Morimoto, L Sistonen - Nature reviews Molecular cell …, 2010 - nature.com
Heat shock factors (HSFs) are essential for all organisms to survive exposures to acute
stress. They are best known as inducible transcriptional regulators of genes encoding …

Cell death mechanisms of plant-derived anticancer drugs: beyond apoptosis

H Gali-Muhtasib, R Hmadi, M Kareh, R Tohme… - Apoptosis, 2015 - Springer
Despite remarkable progress in the discovery and development of novel cancer
therapeutics, cancer remains the second leading cause of death in the world. For many …

Triptolide: progress on research in pharmacodynamics and toxicology

XJ Li, ZZ Jiang, L Zhang - Journal of ethnopharmacology, 2014 - Elsevier
Abstract Ethnopharmacological relevance Tripterygium wilfordii Hook. f.(Tripterygium
wilfordii), also known as Huangteng and gelsemium elegan, is a traditional Chinese …

Triptolide and its expanding multiple pharmacological functions

Q Liu - International immunopharmacology, 2011 - Elsevier
Triptolide, a diterpene triepoxide, is a major active component of extracts derived from the
medicinal plant Tripterygium wilfordii Hook F (TWHF). Triptolide has multiple …

Triptolide: structural modifications, structure–activity relationships, bioactivities, clinical development and mechanisms

ZL Zhou, YX Yang, J Ding, YC Li, ZH Miao - Natural product reports, 2012 - pubs.rsc.org
Covering: 1972 to 2011 Triptolide, a principal bioactive ingredient of Tripterygium wilfordii
Hook F, has attracted extensive exploration due to its unique structure of a diterpenoid …