Nutritional immunity: the battle for nutrient metals at the host–pathogen interface
CC Murdoch, EP Skaar - Nature Reviews Microbiology, 2022 - nature.com
Trace metals are essential micronutrients required for survival across all kingdoms of life.
From bacteria to animals, metals have critical roles as both structural and catalytic cofactors …
From bacteria to animals, metals have critical roles as both structural and catalytic cofactors …
How the PhoP/PhoQ System Controls Virulence and Mg2+ Homeostasis: Lessons in Signal Transduction, Pathogenesis, Physiology, and Evolution
SUMMARY The PhoP/PhoQ two-component system governs virulence, Mg2+ homeostasis,
and resistance to a variety of antimicrobial agents, including acidic pH and cationic …
and resistance to a variety of antimicrobial agents, including acidic pH and cationic …
Enterohaemorrhagic E. coli utilizes host- and microbiota-derived L-malate as a signaling molecule for intestinal colonization
B Liu, L Jiang, Y Liu, H Sun, J Yan, C Kang… - Nature …, 2023 - nature.com
The mammalian gastrointestinal tract is a complex environment that hosts a diverse
microbial community. To establish infection, bacterial pathogens must be able to compete …
microbial community. To establish infection, bacterial pathogens must be able to compete …
Oral magnesium prevents acetaminophen-induced acute liver injury by modulating microbial metabolism
Acetaminophen overuse is a common cause of acute liver failure (ALF). During ALF, toxins
are metabolized by enzymes such as CYP2E1 and transformed into reactive species …
are metabolized by enzymes such as CYP2E1 and transformed into reactive species …
[HTML][HTML] Synthetic bacterial therapies for intestinal diseases based on quorum-sensing circuits
Z Dang, M Gao, L Wang, J Wu, Y Guo, Z Zhu… - Biotechnology …, 2023 - Elsevier
Bacterial therapy has become a key strategy against intestinal infectious diseases in recent
years. Moreover, regulating the gut microbiota through traditional fecal microbiota …
years. Moreover, regulating the gut microbiota through traditional fecal microbiota …
Regulation of flagellar motility and biosynthesis in enterohemorrhagic Escherichia coli O157:H7
H Sun, M Wang, Y Liu, P Wu, T Yao, W Yang… - Gut …, 2022 - Taylor & Francis
ABSTARCT Enterohemorrhagic Escherichia coli (EHEC) O157: H7 is a human pathogen
that causes a variety of diseases, such as hemorrhagic colitis and lethal hemolytic uremic …
that causes a variety of diseases, such as hemorrhagic colitis and lethal hemolytic uremic …
[HTML][HTML] Enterohemorrhagic Escherichia coli senses microbiota-derived nicotinamide to increase its virulence and colonization in the large intestine
W Yang, H Sun, J Yan, C Kang, J Wu, B Yang - Cell Reports, 2023 - cell.com
Summary Enterohemorrhagic Escherichia coli (EHEC) O157: H7 is a foodborne pathogen
that specifically colonizes and infects the human large intestine. EHEC O157: H7 engages …
that specifically colonizes and infects the human large intestine. EHEC O157: H7 engages …
Elucidation of a complete mechanical signaling and virulence activation pathway in enterohemorrhagic Escherichia coli
L Feng, B Yang, Y Xu, Y Xiong, F Wang, B Liu, W Yang… - Cell Reports, 2022 - cell.com
Summary Enterohemorrhagic Escherichia coli (EHEC) O157: H7 is an important
extracellular human pathogen. The initial adherence of EHEC to host cells is a major cue for …
extracellular human pathogen. The initial adherence of EHEC to host cells is a major cue for …
Salmonella invasion is controlled by competition among intestinal chemical signals
R Chowdhury, PD Pavinski Bitar, HM Chapman… - MBio, 2023 - Am Soc Microbiol
The intestine is a complex, ever-changing environment replete with an array of signaling
molecules. To colonize such a complex organ, pathogens have adapted to utilize specific …
molecules. To colonize such a complex organ, pathogens have adapted to utilize specific …
A diffusible signal factor of the intestine dictates Salmonella invasion through its direct control of the virulence activator HilD
R Chowdhury, PD Pavinski Bitar, I Keresztes… - PLoS …, 2021 - journals.plos.org
Successful intestinal infection by Salmonella requires optimized invasion of the gut
epithelium, a function that is energetically costly. Salmonella have therefore evolved to …
epithelium, a function that is energetically costly. Salmonella have therefore evolved to …