Universally fatal only 4 decades ago, the progress in the 3-stage palliation of hypoplastic left
heart syndrome and related single right ventricular lesions has drastically improved the …

The field of gene therapy has evolved over the past two decades after the first introduction of
nucleic acid drugs, such as plasmid DNA (pDNA). With the development of in vitro …

Abstract Hypoplastic Left Heart Syndrome (HLHS) is a complex Congenital Heart Disease
(CHD) that was almost universally fatal until the advent of the Norwood operation in 1981 …

Congenital heart disease (CHD) is the leading cause of infant death, affecting approximately
4–14 live births per 1,000. Although surgical techniques and interventions have improved …

Rationale: Congenital heart disease can lead to life-threatening right ventricular (RV) heart
failure. Results from clinical trials support expanding cardiac progenitor cell (CPC) based …

Hypoplastic left heart syndrome (HLHS) is a complex congenital heart disease in which a
neonate is born with an underdeveloped left ventricle and associated structures. Without …

Newborns with critical congenital heart disease are at significant risk of developing heart
failure later in life. Because treatment options for end-stage heart disease in children are …

Autologous cardiac cell therapy is a promising treatment for combating the right ventricular
heart failure (RVHF) that can occur in patients with congenital heart disease (CHD) …

Methods Our literature review included all full articles published in English language on the
Cochrane, MedLine, and Embase with references to “single ventricle” and “univentricular …

Right ventricular dysfunction is a predictor for worse outcomes in patients with congenital
heart disease. Myocardial ischemia is primarily associated with right ventricular dysfunction …