Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

Overview IL-7 is a member of the family of cytokines with four anti-parallel α helixes that bind
Type I cytokine receptors. It is produced by stromal cells and is required for development …

Improving outcomes in acute myeloid leukemia (AML) remains a major clinical challenge.
Overexpression of pro-survival BCL-2 family members rendering transformed cells resistant …

Autophagy is an intracellular degradation process responsible for the delivery of cellular
material to the lysosomes. One of the key mechanisms for control of autophagy is the …

After their development in the thymus, mature T cells are maintained in the periphery by two
sets of survival signals, namely TCR signals from contact with self-peptide/MHC ligands and …

T cells are pivotal in immunity and immunopathology. After activation, T cells undergo a
clonal expansion and differentiation followed by a contraction phase, once the pathogen has …

Hyperexpression of antiapoptotic BCL-2 family proteins allows cells to survive despite the
receipt of signals that would ordinarily induce their deletion, a facet frequently exploited by …

Cell death on extended mitotic arrest is considered arguably most critical for the efficacy of
microtubule-targeting agents (MTAs) in anticancer therapy. While the molecular machinery …

The thymus is an organ vital to proper T cell development, and the regulation of cell survival
and death contributes significantly to its efficient function. Vital to many of the developmental …

Following acute-phase infection, activated T cells are terminated to achieve immune
homeostasis, failure of which results in lymphoproliferative and autoimmune diseases. We …