Osteosarcoma is one of the most common primary tumours of the bone, with a 5‐year
survival rate of less than 20% after the development of metastases. Osteosarcoma is highly …

Tissue engineering has acquired remarkable attention as an alternative strategy to treat and
restore bone defects during recent years. A scaffold is a fundamental component for tissue …

The differentiation shift from osteogenesis to adipogenesis of bone marrow mesenchymal
stem cells (BMSCs) characterizes many pathological bone loss conditions. Stromal cell …

As bone grafts become more commonly needed by patients and as donors become scarcer,
acellularized bone grafts (ABGs) are becoming more popular for restorative purposes. While …

The present study was to develop a hybrid chitosan-based bionanocomposite for potential
bone tissue engineering applications. Chitosan (C)/Poly (vinyl alcohol)(P)/nano bioactive …

It is well known that bone remodeling starts with a resorption event and ends with bone
formation. However, what happens in between and how resorption and formation are …

Osteal macrophages (osteomacs) support osteoblast function and promote bone anabolism,
but their contribution to osteoporosis has not been explored. Although mouse ovariectomy …

Understanding the in vitro biology and behavior of human osteoblasts is crucial for
developing research models that reproduce closely the bone structure, its functions, and the …

Rapid advancements in traditional bone tissue engineering have led to innovation in bone
repair models and the resolution of insurmountable clinical issues like graft scarcity. The …

Methods In a single-arm, open-label, 36-week prospective trial, we hypothesized that
etelcalcetide improves bone quality and strength without damaging bone–tissue quality …