The role of m6A modification in the biological functions and diseases

X Jiang, B Liu, Z Nie, L Duan, Q Xiong, Z Jin… - Signal transduction and …, 2021 - nature.com
Abstract N6-methyladenosine (m6A) is the most prevalent, abundant and conserved internal
cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells …

m6A methylation regulates osteoblastic differentiation and bone remodeling

M Huang, S Xu, L Liu, M Zhang, J Guo… - Frontiers in cell and …, 2021 - frontiersin.org
Osteoporosis is a prevalent bone disease of the aging population, which is characterized by
a decrease in bone mass because of the imbalance of bone metabolism. Although the …

WTAP-mediated m6A modification of lncRNA DIAPH1-AS1 enhances its stability to facilitate nasopharyngeal carcinoma growth and metastasis

ZX Li, ZQ Zheng, PY Yang, L Lin, GQ Zhou… - Cell Death & …, 2022 - nature.com
As the most predominant RNA epigenetic regulation in eukaryotic cells, N6-
methyladenosine (m6A) plays a critical role in human tumorigenesis and cancer …

METTL14 Regulates Osteogenesis of Bone Marrow Mesenchymal Stem Cells via Inducing Autophagy Through m6A/IGF2BPs/Beclin-1 Signal Axis

M He, H Lei, X He, Y Liu, A Wang, Z Ren… - Stem cells …, 2022 - academic.oup.com
The development of osteoporosis is often accompanied by autophagy disturbance, which
also causes new osteoblast defects from bone marrow mesenchymal stem cells (BMSCs) …

[HTML][HTML] N6-methyladenosine (m6A) methyltransferase WTAP accelerates the Warburg effect of gastric cancer through regulating HK2 stability

H Yu, K Zhao, H Zeng, Z Li, K Chen, Z Zhang… - Biomedicine & …, 2021 - Elsevier
Abstract N 6-methyladenosine (m 6 A) is one of the most abundant messenger RNAs
modification. Increasing evidence illustrates its critical role on gastric cancer. Here, present …

WTAP-mediated m6A modification of lncRNA NORAD promotes intervertebral disc degeneration

G Li, L Ma, S He, R Luo, B Wang, W Zhang… - Nature …, 2022 - nature.com
Abstract N6-methyladenosine (m6A) is the most prevalent RNA modification at the
posttranscriptional level and involved in various diseases and cellular processes. However …

[HTML][HTML] The crosstalk between m6A RNA methylation and other epigenetic regulators: a novel perspective in epigenetic remodeling

Y Zhao, Y Chen, M Jin, J Wang - Theranostics, 2021 - ncbi.nlm.nih.gov
Epigenetic regulation involves a range of sophisticated processes which contribute to
heritable alterations in gene expression without altering DNA sequence. Regulatory events …

MiR‐103‐3p targets the m6A methyltransferase METTL14 to inhibit osteoblastic bone formation

Z Sun, H Wang, Y Wang, G Yuan, X Yu, H Jiang… - Aging cell, 2021 - Wiley Online Library
Impaired osteoblast function is involved in osteoporosis, and microRNA (miRNA)
dysregulation may cause abnormal osteoblast osteogenic activity. However, the influence of …

Novel insights into the interaction between N6‐methyladenosine methylation and noncoding RNAs in musculoskeletal disorders

J Han, H Kong, X Wang, X Zhang - Cell Proliferation, 2022 - Wiley Online Library
Background Musculoskeletal disorder (MSD) are a class of inflammatory and degener‐ative
diseases, but the precise molecular mechanisms are still poorly understood. Noncoding …

Regulation and roles of RNA modifications in aging‐related diseases

Z Jiapaer, D Su, L Hua, HI Lehmann, P Gokulnath… - Aging …, 2022 - Wiley Online Library
With the aging of the global population, accumulating interest is focused on manipulating the
fundamental aging‐related signaling pathways to delay the physiological aging process and …