The role of m6A modification in the biological functions and diseases
X Jiang, B Liu, Z Nie, L Duan, Q Xiong, Z Jin… - Signal transduction and …, 2021 - nature.com
Abstract N6-methyladenosine (m6A) is the most prevalent, abundant and conserved internal
cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells …
cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells …
m6A methylation regulates osteoblastic differentiation and bone remodeling
M Huang, S Xu, L Liu, M Zhang, J Guo… - Frontiers in cell and …, 2021 - frontiersin.org
Osteoporosis is a prevalent bone disease of the aging population, which is characterized by
a decrease in bone mass because of the imbalance of bone metabolism. Although the …
a decrease in bone mass because of the imbalance of bone metabolism. Although the …
WTAP-mediated m6A modification of lncRNA DIAPH1-AS1 enhances its stability to facilitate nasopharyngeal carcinoma growth and metastasis
ZX Li, ZQ Zheng, PY Yang, L Lin, GQ Zhou… - Cell Death & …, 2022 - nature.com
As the most predominant RNA epigenetic regulation in eukaryotic cells, N6-
methyladenosine (m6A) plays a critical role in human tumorigenesis and cancer …
methyladenosine (m6A) plays a critical role in human tumorigenesis and cancer …
METTL14 Regulates Osteogenesis of Bone Marrow Mesenchymal Stem Cells via Inducing Autophagy Through m6A/IGF2BPs/Beclin-1 Signal Axis
M He, H Lei, X He, Y Liu, A Wang, Z Ren… - Stem cells …, 2022 - academic.oup.com
The development of osteoporosis is often accompanied by autophagy disturbance, which
also causes new osteoblast defects from bone marrow mesenchymal stem cells (BMSCs) …
also causes new osteoblast defects from bone marrow mesenchymal stem cells (BMSCs) …
[HTML][HTML] N6-methyladenosine (m6A) methyltransferase WTAP accelerates the Warburg effect of gastric cancer through regulating HK2 stability
H Yu, K Zhao, H Zeng, Z Li, K Chen, Z Zhang… - Biomedicine & …, 2021 - Elsevier
Abstract N 6-methyladenosine (m 6 A) is one of the most abundant messenger RNAs
modification. Increasing evidence illustrates its critical role on gastric cancer. Here, present …
modification. Increasing evidence illustrates its critical role on gastric cancer. Here, present …
WTAP-mediated m6A modification of lncRNA NORAD promotes intervertebral disc degeneration
G Li, L Ma, S He, R Luo, B Wang, W Zhang… - Nature …, 2022 - nature.com
Abstract N6-methyladenosine (m6A) is the most prevalent RNA modification at the
posttranscriptional level and involved in various diseases and cellular processes. However …
posttranscriptional level and involved in various diseases and cellular processes. However …
[HTML][HTML] The crosstalk between m6A RNA methylation and other epigenetic regulators: a novel perspective in epigenetic remodeling
Y Zhao, Y Chen, M Jin, J Wang - Theranostics, 2021 - ncbi.nlm.nih.gov
Epigenetic regulation involves a range of sophisticated processes which contribute to
heritable alterations in gene expression without altering DNA sequence. Regulatory events …
heritable alterations in gene expression without altering DNA sequence. Regulatory events …
MiR‐103‐3p targets the m6A methyltransferase METTL14 to inhibit osteoblastic bone formation
Z Sun, H Wang, Y Wang, G Yuan, X Yu, H Jiang… - Aging cell, 2021 - Wiley Online Library
Impaired osteoblast function is involved in osteoporosis, and microRNA (miRNA)
dysregulation may cause abnormal osteoblast osteogenic activity. However, the influence of …
dysregulation may cause abnormal osteoblast osteogenic activity. However, the influence of …
Novel insights into the interaction between N6‐methyladenosine methylation and noncoding RNAs in musculoskeletal disorders
J Han, H Kong, X Wang, X Zhang - Cell Proliferation, 2022 - Wiley Online Library
Background Musculoskeletal disorder (MSD) are a class of inflammatory and degener‐ative
diseases, but the precise molecular mechanisms are still poorly understood. Noncoding …
diseases, but the precise molecular mechanisms are still poorly understood. Noncoding …
Regulation and roles of RNA modifications in aging‐related diseases
With the aging of the global population, accumulating interest is focused on manipulating the
fundamental aging‐related signaling pathways to delay the physiological aging process and …
fundamental aging‐related signaling pathways to delay the physiological aging process and …