Multifaceted role of neuropilins in the immune system: potential targets for immunotherapy

S Roy, AK Bag, RK Singh, JE Talmadge… - Frontiers in …, 2017 - frontiersin.org
Neuropilins (NRPs) are non-tyrosine kinase cell surface glycoproteins expressed in all
vertebrates and widely conserved across species. The two isoforms, such as neuropilin-1 …

Sialylation of N-glycans: mechanism, cellular compartmentalization and function

GP Bhide, KJ Colley - Histochemistry and cell biology, 2017 - Springer
Sialylated N-glycans play essential roles in the immune system, pathogen recognition and
cancer. This review approaches the sialylation of N-glycans from three perspectives. The …

Sialylation is involved in cell fate decision during development, reprogramming and cancer progression

F Li, J Ding - Protein & cell, 2019 - academic.oup.com
Sialylation, or the covalent addition of sialic acid to the terminal end of glycoproteins, is a
biologically important modification that is involved in embryonic development …

[HTML][HTML] Microglia at center stage: a comprehensive review about the versatile and unique residential macrophages of the central nervous system

N Lannes, E Eppler, S Etemad, P Yotovski, L Filgueira - Oncotarget, 2017 - ncbi.nlm.nih.gov
Microglia cells are the unique residential macrophages of the central nervous system (CNS).
They have a special origin, as they derive from the embryonic yolk sac and enter the …

Sialometabolism in brain health and Alzheimer's disease

P Rawal, L Zhao - Frontiers in Neuroscience, 2021 - frontiersin.org
Sialic acids refer to a unique family of acidic sugars with a 9-carbon backbone that are
mostly found as terminal residues in glycan structures of glycoconjugates including both …

Polysialic acid is a cellular receptor for human adenovirus 52

A Lenman, AM Liaci, Y Liu… - Proceedings of the …, 2018 - National Acad Sciences
Human adenovirus 52 (HAdV-52) is one of only three known HAdVs equipped with both a
long and a short fiber protein. While the long fiber binds to the coxsackie and adenovirus …

Sialylation acts as a checkpoint for innate immune responses in the central nervous system

C Klaus, H Liao, DH Allendorf, GC Brown, H Neumann - Glia, 2021 - Wiley Online Library
Sialic acids are monosaccharides that normally terminate the glycan chains of cell surface
glyco‐proteins and‐lipids in mammals, and are highly enriched in the central nervous tissue …

The versatile roles of ADAM8 in cancer cell migration, mechanics, and extracellular matrix remodeling

CT Mierke - Frontiers in cell and developmental biology, 2023 - frontiersin.org
The posttranslational proteolytic cleavage is a unique and irreversible process that governs
the function and half-life of numerous proteins. Thereby the role of the family of A disintegrin …

E-selectin in vascular pathophysiology

J Zhang, S Huang, Z Zhu, A Gatt, J Liu - Frontiers in immunology, 2024 - frontiersin.org
Selectins are a group of Ca2+-dependent, transmembrane type I glycoproteins which attract
cell adhesion and migration. E-selectin is exclusively expressed in endothelial cells, and its …

ADAM8 expression in breast cancer derived brain metastases: functional implications on MMP‐9 expression and transendothelial migration in breast cancer cells

C Conrad, M Götte, U Schlomann… - … journal of cancer, 2018 - Wiley Online Library
Metastatic breast cancer affects long‐term survival and is a major cause of cancer death for
women worldwide. The Metalloprotease‐Disintegrin ADAM8 promotes breast cancer …