Metabolomics and type 2 diabetes risk: an updated systematic review and meta-analysis of prospective cohort studies

J Morze, C Wittenbecher, L Schwingshackl… - Diabetes …, 2022 - Am Diabetes Assoc
BACKGROUND Due to the rapidly increasing availability of metabolomics data in
prospective studies, an update of the meta evidence on metabolomics and type 2 diabetes …

Metabolomics and proteomics in type 2 diabetes

ZZ Chen, RE Gerszten - Circulation research, 2020 - Am Heart Assoc
The persistent increase in the worldwide burden of type 2 diabetes mellitus (T2D) and the
accompanying rise of its complications, including cardiovascular disease, necessitates our …

Integrative modeling of quantitative plasma lipoprotein, metabolic, and amino acid data reveals a multiorgan pathological signature of SARS-CoV-2 infection

T Kimhofer, S Lodge, L Whiley, N Gray… - Journal of proteome …, 2020 - ACS Publications
The metabolic effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection on human blood plasma were characterized using multiplatform metabolic …

Metabolic architecture of acute exercise response in middle-aged adults in the community

M Nayor, RV Shah, PE Miller, JB Blodgett, M Tanguay… - Circulation, 2020 - Am Heart Assoc
Background: Whereas regular exercise is associated with lower risk of cardiovascular
disease and mortality, mechanisms of exercise-mediated health benefits remain less clear …

[HTML][HTML] The plasma metabolome of long COVID patients two years after infection

Y López-Hernández, J Monárrez-Espino, DAG López… - Scientific reports, 2023 - nature.com
One of the major challenges currently faced by global health systems is the prolonged
COVID-19 syndrome (also known as “long COVID”) which has emerged as a consequence …

[HTML][HTML] Amino acids, microbiota-related metabolites, and the risk of incident diabetes among normoglycemic Chinese adults: Findings from the 4C study

S Wang, M Li, H Lin, G Wang, Y Xu, X Zhao, C Hu… - Cell Reports …, 2022 - cell.com
Although previous studies suggest that amino acids (AAs) and microbiota-related
metabolites (MRMs) are associated with type 2 diabetes mellitus (T2DM), the results remain …

[HTML][HTML] Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts

JA Rothwell, J Bešević, N Dimou, M Breeur, N Murphy… - BMC medicine, 2023 - Springer
Background Amino acid metabolism is dysregulated in colorectal cancer patients; however,
it is not clear whether pre-diagnostic levels of amino acids are associated with subsequent …

Dietary metabolic signatures and cardiometabolic risk

RV Shah, LM Steffen, M Nayor, JP Reis… - European heart …, 2023 - academic.oup.com
Aims Observational studies of diet in cardiometabolic-cardiovascular disease (CM-CVD)
focus on self-reported consumption of food or dietary pattern, with limited information on …

[HTML][HTML] Metabolic perspective of astrocyte dysfunction in Alzheimer's disease and type 2 diabetes brains

Z Shen, ZY Li, MT Yu, KL Tan, S Chen - Biomedicine & pharmacotherapy, 2023 - Elsevier
The term type III diabetes (T3DM) has been proposed for Alzheimer's disease (AD) due to
the shared molecular and cellular features between type 2 diabetes (T2DM) and insulin …

[HTML][HTML] Integrative plasma metabolic and lipidomic modelling of SARS-CoV-2 infection in relation to clinical severity and early mortality prediction

S Lodge, NG Lawler, N Gray, R Masuda… - International Journal of …, 2023 - mdpi.com
An integrative multi-modal metabolic phenotyping model was developed to assess the
systemic plasma sequelae of SARS-CoV-2 (rRT-PCR positive) induced COVID-19 disease …